Anthrax Vaccine Design: Strategies to Achieve Comprehensive Protection Against Spore, Bacillus, and Toxin

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Anthrax Vaccine Design: Strategies to Achieve Comprehensive Protection Against Spore, Bacillus, and Toxin

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Title: Anthrax Vaccine Design: Strategies to Achieve Comprehensive Protection Against Spore, Bacillus, and Toxin
Author: Roehrl, Michael H; Wang, Jun-Xia

Note: Order does not necessarily reflect citation order of authors.

Citation: Wang, Julia Y, and Michael H Roehrl. 2005. Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin. Medical Immunology 4: 4.
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Abstract: The successful use of Bacillus anthracis as a lethal biological weapon has prompted renewed research interest in the development of more effective vaccines against anthrax. The disease consists of three critical components: spore, bacillus, and toxin, elimination of any of which confers at least partial protection against anthrax. Current remedies rely on postexposure antibiotics to eliminate bacilli and pre- and postexposure vaccination to target primarily toxins. Vaccines effective against toxin have been licensed for human use, but need improvement. Vaccines against bacilli have recently been developed by us and others. Whether effective vaccines will be developed against spores is still an open question. An ideal vaccine would confer simultaneous protection against spores, bacilli, and toxins. One step towards this goal is our dually active vaccine, designed to destroy both bacilli and toxin. Existing and potential strategies towards potent and effective anthrax vaccines are discussed in this review.
Published Version: doi://10.1186/1476-9433-4-4
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079933/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:7628586
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