Show simple item record

dc.contributor.authorSong, Yiqing
dc.contributor.authorCook, Nancy Romanowicz
dc.contributor.authorAlbert, Christine Marie
dc.contributor.authorVan Denburgh, Martin
dc.contributor.authorManson, JoAnn Elisabeth
dc.date.accessioned2012-01-21T01:34:22Z
dc.date.issued2009
dc.identifier.citationSong, Yiqing, Nancy R. Cook, Christine M. Albert, Martin Van Denburgh, and JoAnn E. Manson. 2009. Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of Type 2 diabetes in women. Diabetes 58(8): 1921-1928.en_US
dc.identifier.issn0012-1797en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8000903
dc.description.abstractOBJECTIVE: Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering treatment by B vitamin supplementation prevents the risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: The Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a randomized, double-blind, placebo-controlled trial of 5,442 female health professionals aged ≥40 years with a history of cardiovascular disease (CVD) or three or more CVD risk factors, included 4,252 women free of diabetes at baseline. Participants were randomly assigned to either an active treatment group (daily intake of a combination pill of 2.5 mg folic acid, 50 mg vitamin B6, and 1 mg vitamin B12) or to the placebo group. RESULTS: During a median follow-up of 7.3 years, 504 women had an incident diagnosis of type 2 diabetes. Overall, there was no significant difference between the active treatment group and the placebo group in diabetes risk (relative risk 0.94 [95% CI 0.79–1.11]; P = 0.46), despite significant lowering of homocysteine levels. Also, there was no evidence for effect modifications by baseline intakes of dietary folate, vitamin B6, and vitamin B12. In a sensitivity analysis, the null result remained for women compliant with their study pills (0.92 [0.76–1.10]; P = 0.36). CONCLUSIONS: Lowering homocysteine levels by daily supplementation with folic acid and vitamins B6 and B12 did not reduce the risk of developing type 2 diabetes among women at high risk for CVD.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi://10.2337/db09-0087en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712772/pdf/en_US
dash.licenseLAA
dc.subjectpharmacology and therapeuticsen_US
dc.titleEffect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins on Risk of Type 2 Diabetes in Womenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetesen_US
dash.depositing.authorSong, Yiqing
dc.date.available2012-01-21T01:34:22Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.2337/db09-0087*
dash.contributor.affiliatedCook, Nancy
dash.contributor.affiliatedAlbert, Christine
dash.contributor.affiliatedSong, Yiqing
dash.contributor.affiliatedManson, JoAnn
dc.identifier.orcid0000-0002-9426-7595


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record