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dc.contributor.authorJayet, Pierre-Yves
dc.contributor.authorSchindler, Christian
dc.contributor.authorKünzli, Nino
dc.contributor.authorZellweger, Jean-Pierre
dc.contributor.authorBrändli, Otto
dc.contributor.authorPerruchoud, André Paul
dc.contributor.authorKeller, Roland
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorAckermann-Liebrich, Ursula
dc.contributor.authorLeuenberger, Philippe
dc.date.accessioned2012-01-21T02:14:32Z
dc.date.issued2005
dc.identifier.citationJayet, Pierre-Yves, Christian Schindler, Nino Künzli, Jean-Pierre Zellweger, Otto Brändli, André Paul Perruchoud, Roland Keller, Joel Schwartz, Ursula Ackermann-Liebrich, Philippe Leuenberger, and SAPALDIA team. 2005. Reference values for methacholine reactivity (SAPALDIA study). Respiratory Research 6(1): 131.en_US
dc.identifier.issn1465-9921en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8000913
dc.description.abstractBackground: The distribution of airway responsiveness in a general population of non-smokers without respiratory symptoms has not been established, limiting its use in clinical and epidemiological practice. We derived reference equations depending on individual characteristics (i.e., sex, age, baseline lung function) for relevant percentiles of the methacholine two-point dose-response slope. Methods: In a reference sample of 1567 adults of the SAPALDIA cross-sectional survey (1991), defined by excluding subjects with respiratory conditions, responsiveness during methacholine challenge was quantified by calculating the two-point dose-response slope (O'Connor). Weighted L1-regression was used to estimate reference equations for the 95th , 90th , 75th and 50th percentiles of the two-point slope. Results: Reference equations for the 95th , 90th , 75th and 50th percentiles of the two-point slope were estimated using a model of the form a + b* Age + c* FEV\(_1\) + d* (FEV\(_1\))\(^2\) , where FEV\(_1\) corresponds to the pre-test (or baseline) level of FEV\(_1\). For the central half of the FEV\(_1\) distribution, we used a quadratic model to describe the dependence of methacholine slope on baseline FEV\(_1\). For the first and last quartiles of FEV\(_1\), a linear relation with FEV\(_1\) was assumed (i.e., d was set to 0). Sex was not a predictor term in this model. A negative linear association with slope was found for age. We provide an Excel file allowing calculation of the percentile of methacholine slope of a subject after introducing age – pre-test FEV\(_1\) – and results of methacholine challenge of the subject. Conclusion: The present study provides equations for four relevant percentiles of methacholine two-point slope depending on age and baseline FEV\(_1\) as basic predictors in an adult reference population of non-obstructive and non-atopic persons. These equations may help clinicians and epidemiologists to better characterize individual or population airway responsiveness.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1465-9921-6-131en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298336/pdf/en_US
dash.licenseLAA
dc.titleReference Values for Methacholine Reactivity (SAPALDIA Study)en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalRespiratory Researchen_US
dash.depositing.authorSchwartz, Joel David
dc.date.available2012-01-21T02:14:32Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1186/1465-9921-6-131*
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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