The Recycling and Transcytotic Pathways for IgG Transport by FcRn are Distinct and Display an Inherent Polarity

View/ Open
Author
Hamman, Wendy
Lapierre, Lynne A.
Goldenring, James R.
Published Version
https://doi.org/10.1083/jcb.200809122Metadata
Show full item recordCitation
Tzaban, Salit, Ramiro H. Massol, Elizabeth Yen, Wendy Hamman, Scott R. Frank, Lynne A. Lapierre, Steen H. Hansen, James R. Goldenring, Richard S. Blumberg, and Wayne I. Lencer. 2009. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. Journal of Cell Biology 185(4): 673-684.Abstract
The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense. We show that FcRn traffics IgG from either apical or basolateral membranes into the recycling endosome (RE), after which the actin motor myosin Vb and the GTPase Rab25 regulate a sorting step that specifies transcytosis without affecting recycling. Another regulatory component of the RE, Rab11a, is dispensable for transcytosis, but regulates recycling to the basolateral membrane only. None of these proteins affect FcRn trafficking away from lysosomes. Thus, FcRn transcytotic and recycling sorting steps are distinct. These results are consistent with a single structurally and functionally heterogeneous RE compartment that traffics FcRn to both cell surfaces while discriminating between recycling and transcytosis pathways polarized in their direction of transport.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711563/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:8015281
Collections
- HMS Scholarly Articles [18278]
Contact administrator regarding this item (to report mistakes or request changes)