Monitoring Processed, Mature Human Immunodeficiency Virus Type 1 Particles Immediately Following Treatment with a Protease Inhibitor-containing Treatment Regimen

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Monitoring Processed, Mature Human Immunodeficiency Virus Type 1 Particles Immediately Following Treatment with a Protease Inhibitor-containing Treatment Regimen

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Title: Monitoring Processed, Mature Human Immunodeficiency Virus Type 1 Particles Immediately Following Treatment with a Protease Inhibitor-containing Treatment Regimen
Author: Baird, Heather A; Marozsan, Andre J; Lederman, Michael M; Landay, Alan; Mildvan, Donna; Kessler, Harold A; Arts, Eric J; Kuritzkes, Daniel Robert

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Citation: Baird, Heather A, Andre J Marozsan, Michael M Lederman, Alan Landay, Donna Mildvan, Daniel R Kuritzkes, Harold A Kessler, and Eric J Arts. 2005. Monitoring processed, mature Human Immunodeficiency Virus type 1 particles immediately following treatment with a protease inhibitor-containing treatment regimen. AIDS Research and Therapy 2: 2.
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Abstract: Protease inhibitors (PIs) block HIV-1 maturation into an infectious virus particle by inhibiting the protease processing of gag and gag-pol precursor proteins. We have used a simple anti-HIV-1 p24 Western blot to monitor the processing of p55\(^{\text{gag}}\) precursor into the mature p24 capsid immediately following the first dosage of a PI-containing treatment regimen. Evidence of PI activity was observed in plasma virus as early as 72 hours post treatment-initiation and was predictive of plasma viral RNA decrease at 4 weeks.
Published Version: doi://10.1186/1742-6405-2-2
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087826/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8097015
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