Primate-specific Evolution of an LDLR Enhancer

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Primate-specific Evolution of an LDLR Enhancer

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Title: Primate-specific Evolution of an LDLR Enhancer
Author: Wang, Qian-fei; Prabhakar, Shyam; Wang, Qianben; Moses, Alan M; Chanan, Sumita; Eisen, Michael B; Cheng, Jan-Fang; Rubin, Edward M; Boffelli, Dario; Brown, Myles Avery

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Citation: Wang, Qian-fei, Shyam Prabhakar, Qianben Wang, Alan M Moses, Sumita Chanan, Myles Brown, Michael B Eisen, Jan-Fang Cheng, Edward M Rubin, and Dario Boffelli. 2006. Primate-specific evolution of an enhancer. Genome Biology 7(8): R68.
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Abstract: Background: Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. Results: In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates. Conclusion: Our study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.
Published Version: doi://10.1186/gb-2006-7-8-r68
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