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dc.contributor.authorWang, Qian-fei
dc.contributor.authorPrabhakar, Shyam
dc.contributor.authorWang, Qianben
dc.contributor.authorMoses, Alan M
dc.contributor.authorChanan, Sumita
dc.contributor.authorEisen, Michael B
dc.contributor.authorCheng, Jan-Fang
dc.contributor.authorRubin, Edward M
dc.contributor.authorBoffelli, Dario
dc.contributor.authorBrown, Myles Avery
dc.date.accessioned2012-02-03T05:06:07Z
dc.date.issued2006
dc.identifier.citationWang, Qian-fei, Shyam Prabhakar, Qianben Wang, Alan M Moses, Sumita Chanan, Myles Brown, Michael B Eisen, Jan-Fang Cheng, Edward M Rubin, and Dario Boffelli. 2006. Primate-specific evolution of an enhancer. Genome Biology 7(8): R68.en_US
dc.identifier.issn1465-6906en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8097018
dc.description.abstractBackground: Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. Results: In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates. Conclusion: Our study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/gb-2006-7-8-r68en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779597/pdf/en_US
dash.licenseLAA
dc.titlePrimate-specific Evolution of an LDLR Enhanceren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Biologyen_US
dash.depositing.authorBrown, Myles Avery
dc.date.available2012-02-03T05:06:07Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1186/gb-2006-7-8-r68*
dash.authorsorderedfalse
dash.contributor.affiliatedBrown, Myles


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