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dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorBiederman, Joseph
dc.contributor.authorSpencer, Thomas J.
dc.contributor.authorMichelson, David
dc.contributor.authorAdler, Lenard
dc.contributor.authorReimherr, Fred
dc.contributor.authorGlatt, Stephen J
dc.date.accessioned2012-02-05T22:22:59Z
dc.date.issued2005
dc.identifier.citationFaraone, Stephen V., Joseph Biederman, Thomas Spencer, David Michelson, Lenard Adler, Fred Reimherr, and Stephen J. Glatt. 2005. Efficacy of atomoxetine in adult attention-Deficit/Hyperactivity Disorder: a drug-placebo response curve analysis. Behavioral and Brain Functions 1: 16.en_US
dc.identifier.issn1744-9081en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8123180
dc.description.abstractBackground: The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD) among adults by using drug-placebo response curve methods. Methods: We analyzed data from two double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N = 256) with DSM-IV-defined ADHD who were recruited by referral and advertising. Subjects were randomized to 10 weeks of treatment with atomoxetine or placebo, and were assessed with the Conners Adult ADHD Rating Scales and the Clinical Global Impression of ADHD Severity scale before and after treatment. Results: Those treated with atomoxetine were more likely to show a reduction in ADHD symptoms than those receiving placebo. Across all measures, the likelihood that an atomoxetine-treated subject improved to a greater extent than a placebo-treated subject was approximately 0.60. Furthermore, atomoxetine prevented worsening of most symptom classes. Conclusion: From these findings, we conclude that atomoxetine is an effective treatment for ADHD among adults when evaluated using several criteria.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1744-9081-1-16en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262689/pdf/en_US
dash.licenseLAA
dc.titleEfficacy of Atomoxetine in Adult Attention-Deficit/Hyperactivity Disorder: A Drug-placebo Response Curve Analysisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBehavioral and Brain Functionsen_US
dash.depositing.authorBiederman, Joseph
dc.date.available2012-02-05T22:22:59Z
dash.affiliation.otherHMS^Psychiatry-Massachusetts General Hospitalen_US
dc.identifier.doi10.1186/1744-9081-1-16*
dash.contributor.affiliatedSpencer, Thomas
dash.contributor.affiliatedFaraone, Stephen
dash.contributor.affiliatedBiederman, Joseph


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