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dc.contributor.authorMeeker, John D.
dc.contributor.authorCalafat, Antonia M.
dc.contributor.authorHauser, Russ B.
dc.date.accessioned2012-02-09T20:47:49Z
dc.date.issued2007
dc.identifier.citationMeeker, John D., Antonia M. Calafat, and Russ Hauser. 2007. Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environmental Health Perspectives 115(7): 1029-1034.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8148899
dc.description.abstractBackground: Phthalates are used extensively in many personal-care and consumer products, resulting in widespread nonoccupational human exposure through multiple routes and media. A limited number of animal studies suggest that exposure to phthalates may be associated with altered thyroid function, but human data are lacking. Methods: Concurrent samples of urine and blood were collected from 408 men. We measured urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP), the hydrolytic metabolite of di(2-ethylhexyl) phthalate (DEHP), and other phthalate monoester metabolites, along with serum levels of free thyroxine (T\(_4\)), total triiodothyronine (T\(_3\)), and thyroid-stimulating hormone (TSH). Oxidative metabolites of DEHP were measured in urine from only 208 of the men. Results: We found an inverse association between MEHP urinary concentrations and free T\(_4\) and T\(_3\) serum levels, although the relationships did not appear to be linear when MEHP concentrations were categorized by quintiles. There was evidence of a plateau at the fourth quintile, which was associated with a 0.11 ng/dL decrease in free T\(_4\) [95% confidence interval (CI), –0.18 to –0.03] and a 0.05 ng/mL decrease in T\(_3\) (95% CI, –0.10 to 0.01) compared with the first (lowest) MEHP quintile. The inverse relationship between MEHP and free T\(_4\) remained when we adjusted for oxidative metabolite concentrations; this simultaneously demonstrated a suggestive positive association with free T\(_4\). Conclusions: Urinary MEHP concentrations may be associated with altered free T\(_4\) and/or total T\(_3\) levels in adult men, but additional study is needed to confirm the observed findings. Future studies must also consider oxidative DEHP metabolites relative to MEHP as a potential marker of metabolic susceptibility to DEHP exposure.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.9852en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913587/pdf/en_US
dash.licenseLAA
dc.subjectbiomarkersen_US
dc.subjectendocrine disruptionen_US
dc.subjectepidemiologyen_US
dc.subjecthormoneen_US
dc.subjectphthalatesen_US
dc.subjectthyroiden_US
dc.subjecturinary metabolitesen_US
dc.titleDi(2-ethylhexyl) Phthalate Metabolites May Alter Thyroid Hormone Levels in Menen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorHauser, Russ B.
dc.date.available2012-02-09T20:47:49Z
dash.affiliation.otherHMS^Obstetrics Gynecology and Repro. Bio. - MGHen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.9852*
dash.contributor.affiliatedHauser, Russ


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