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dc.contributor.authorFardo, David W.
dc.contributor.authorIonita-Laza, Iuliana
dc.contributor.authorDermitzakis, Emmanouil T.
dc.contributor.authorLange, Christoph
dc.date.accessioned2012-02-12T04:55:32Z
dc.date.issued2009
dc.identifier.citationFardo, David W., Iuliana Ionita-Laza, and Christoph Lange. 2009. On quality control measures in genome-wide association studies: A test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data. PLoS Genetics 5(7): e1000572.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8156570
dc.description.abstractAllele transmissions in pedigrees provide a natural way of evaluating the genotyping quality of a particular proband in a family-based, genome-wide association study. We propose a transmission test that is based on this feature and that can be used for quality control filtering of genome-wide genotype data for individual probands. The test has one degree of freedom and assesses the average genotyping error rate of the genotyped SNPs for a particular proband. As we show in simulation studies, the test is sufficiently powerful to identify probands with an unreliable genotyping quality that cannot be detected with standard quality control filters. This feature of the test is further exemplified by an application to the third release of the HapMap data. The test is ideally suited as the final layer of quality control filters in the cleaning process of genome-wide association studies. It identifies probands with insufficient genotyping quality that were not removed by standard quality control filtering.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi://10.1371/journal.pgen.1000572en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706974/pdf/en_US
dash.licenseLAA
dc.subjectgenetics and genomicsen_US
dc.subjectcomplex traitsen_US
dc.subjectmathematicsen_US
dc.subjectstatisticsen_US
dc.titleOn Quality Control Measures in Genome-wide Association Studies: A Test to Assess the Genotyping Quality of Individual Probands in Family-based Association Studies and an Application to the HapMap Dataen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorLange, Christoph
dc.date.available2012-02-12T04:55:32Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dc.identifier.doi10.1371/journal.pgen.1000572*
dash.authorsorderedfalse
dash.contributor.affiliatedLange, Christoph


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