Identifying Targets for COPD Treatment Through Gene Expression Analyses

DSpace/Manakin Repository

Identifying Targets for COPD Treatment Through Gene Expression Analyses

Citable link to this page


Title: Identifying Targets for COPD Treatment Through Gene Expression Analyses
Author: Chen, Zhi-Hua; Kim, Hong Pyo; Ryter, Stefan W.; Choi, Augustine M.K.

Note: Order does not necessarily reflect citation order of authors.

Citation: Chen, Zhi-Hua, Hong Pyo Kim, Stefan W Ryter, and Augustine MK Choi. 2008. Identifying targets for COPD treatment through gene expression analyses. International Journal of Chronic Obstructive Pulmonary Disease 3(3): 359-370.
Full Text & Related Files:
Abstract: Despite the status of chronic obstructive pulmonary disease (COPD) as a major global health problem, no currently available therapies can limit COPD progression. Therefore, an urgent need exists for the development of new and effective treatments for COPD. An improved understanding in the molecular pathogenesis of COPD can potentially identify molecular targets to facilitate the development of new therapeutic modalities. Among the best approaches for understanding the molecular basis of COPD include gene expression profiling techniques, such as serial analysis of gene expression or microarrays. Using these methods, recent studies have mapped comparative gene expression profiles of lung tissues from patients with different stages of COPD relative to healthy smokers or non-smokers. Such studies have revealed a number of differentially-regulated genes associated with COPD progression, which include genes involved in the regulation of inflammation, extracellular matrix, cytokines, chemokines, apoptosis, and stress responses. These studies have shed new light on the molecular mechanisms of COPD, and suggest novel targets for clinical treatments.
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search