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dc.contributor.authorChen, Zhi-Hua
dc.contributor.authorKim, Hong Pyo
dc.contributor.authorRyter, Stefan W.
dc.contributor.authorChoi, Augustine M.K.
dc.date.accessioned2012-02-12T04:58:45Z
dc.date.issued2008
dc.identifier.citationChen, Zhi-Hua, Hong Pyo Kim, Stefan W Ryter, and Augustine MK Choi. 2008. Identifying targets for COPD treatment through gene expression analyses. International Journal of Chronic Obstructive Pulmonary Disease 3(3): 359-370.en_US
dc.identifier.issn1176-9106en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8156571
dc.description.abstractDespite the status of chronic obstructive pulmonary disease (COPD) as a major global health problem, no currently available therapies can limit COPD progression. Therefore, an urgent need exists for the development of new and effective treatments for COPD. An improved understanding in the molecular pathogenesis of COPD can potentially identify molecular targets to facilitate the development of new therapeutic modalities. Among the best approaches for understanding the molecular basis of COPD include gene expression profiling techniques, such as serial analysis of gene expression or microarrays. Using these methods, recent studies have mapped comparative gene expression profiles of lung tissues from patients with different stages of COPD relative to healthy smokers or non-smokers. Such studies have revealed a number of differentially-regulated genes associated with COPD progression, which include genes involved in the regulation of inflammation, extracellular matrix, cytokines, chemokines, apoptosis, and stress responses. These studies have shed new light on the molecular mechanisms of COPD, and suggest novel targets for clinical treatments.en_US
dc.language.isoen_USen_US
dc.publisherDove Medical Pressen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629979/pdf/en_US
dash.licenseLAA
dc.subjectCOPDen_US
dc.subjectgene expressionen_US
dc.subjecttherapeutic targetsen_US
dc.titleIdentifying Targets for COPD Treatment Through Gene Expression Analysesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalInternational Journal of Chronic Obstructive Pulmonary Diseaseen_US
dash.depositing.authorRyter, Stefan W.
dc.date.available2012-02-12T04:58:45Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Molecular+Integrative Physiological Sci Progen_US
dc.identifier.doi10.2147/COPD.S1758
dash.contributor.affiliatedChoi, Augustine M.K.
dash.contributor.affiliatedRyter, Stefan W.


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