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dc.contributor.authorWheeler, Amanda
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorGold, Diane R.
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorStone, Peter Howard
dc.contributor.authorSuh MacIntosh, Helen H.
dc.date.accessioned2012-02-12T05:05:49Z
dc.date.issued2005
dc.identifier.citationWheeler, Amanda, Antonella Zanobetti, Diane R. Gold, Joel Schwartz, Peter Stone, and Helen H. Suh. 2006. The relationship between ambient air pollution and heart rate variability differs for individuals with heart and pulmonary disease. Environmental Health Perspectives 114(4): 560-566.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8156573
dc.description.abstractAssociations between concentrations of ambient fine particles [particulate matter < 2.5 μm aerodynamic diameter (PM\(_{2.5}\))] and heart rate variability (HRV) have differed by study population. We examined the effects of ambient pollution on HRV for 18 individuals with chronic obstructive pulmonary disease (COPD) and 12 individuals with recent myocardial infarction (MI) living in Atlanta, Georgia. HRV, baseline pulmonary function, and medication data were collected for each participant on 7 days in fall 1999 and/or spring 2000. Hourly ambient pollution concentrations were obtained from monitoring sites in Atlanta. The association between ambient pollution and HRV was examined using linear mixed-effect models. Ambient pollution had opposing effects on HRV in our COPD and MI participants, resulting in no significant effect of ambient pollution on HRV in the entire population for 1-, 4-, or 24-hr moving averages. For individuals with COPD, interquartile range (IQR) increases in 4-hr ambient PM\(_{2.5}\) (11.65 μg/m\(^3\)) and nitrogen dioxide (11.97 ppb) were associated with 8.3% [95% confidence interval (CI), 1.7–15.3%] and 7.7% (95% CI, 0.1–15.9%) increase in the SD of normal R-R intervals (SDNN), respectively. For individuals with MI, IQR increases in 4-hr PM\(_{2.5}\) (8.54 μg/m\(^3\)) and NO2 (9.25 ppb) were associated with a nonsignificant 2.9% (95% CI, –7.8 to 2.3) and significant 12.1 (95% CI, –19.5 to –4.0) decrease in SDNN. Beta-blocker and bronchodilator intake and baseline forced expiratory volume in 1 sec modified the PM–SDNN association significantly, with effects consistent with those by disease group. Results indicate heterogeneity in the autonomic response to air pollution due to differences in baseline health, with significant associations for ambient NO2 suggesting an important role for traffic-related pollution.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi://10.1289/ehp.8337en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440781/pdf/en_US
dash.licenseLAA
dc.subjectambient pollutionen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectfine particulate matteren_US
dc.subjectheart rate variabilityen_US
dc.subjectmyocardial infarctionsen_US
dc.subjectnitrogen dioxideen_US
dc.titleThe Relationship Between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Diseaseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorZanobetti, Antonella
dc.date.available2012-02-12T05:05:49Z
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1289/ehp.8337*
dash.authorsorderedfalse
dash.contributor.affiliatedStone, Peter
dash.contributor.affiliatedSuh MacIntosh, Helen H.
dash.contributor.affiliatedGold, Diane
dash.contributor.affiliatedZanobetti, Antonella
dash.contributor.affiliatedSchwartz, Joel


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