The Relationship Between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Disease

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The Relationship Between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Disease

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dc.contributor.author Wheeler, Amanda
dc.contributor.author Zanobetti, Antonella
dc.contributor.author Gold, Diane R.
dc.contributor.author Schwartz, Joel David
dc.contributor.author Stone, Peter Howard
dc.contributor.author Suh MacIntosh, Helen H.
dc.date.accessioned 2012-02-12T05:05:49Z
dc.date.issued 2005
dc.identifier.citation Wheeler, Amanda, Antonella Zanobetti, Diane R. Gold, Joel Schwartz, Peter Stone, and Helen H. Suh. 2006. The relationship between ambient air pollution and heart rate variability differs for individuals with heart and pulmonary disease. Environmental Health Perspectives 114(4): 560-566. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8156573
dc.description.abstract Associations between concentrations of ambient fine particles [particulate matter < 2.5 μm aerodynamic diameter (PM\(_{2.5}\))] and heart rate variability (HRV) have differed by study population. We examined the effects of ambient pollution on HRV for 18 individuals with chronic obstructive pulmonary disease (COPD) and 12 individuals with recent myocardial infarction (MI) living in Atlanta, Georgia. HRV, baseline pulmonary function, and medication data were collected for each participant on 7 days in fall 1999 and/or spring 2000. Hourly ambient pollution concentrations were obtained from monitoring sites in Atlanta. The association between ambient pollution and HRV was examined using linear mixed-effect models. Ambient pollution had opposing effects on HRV in our COPD and MI participants, resulting in no significant effect of ambient pollution on HRV in the entire population for 1-, 4-, or 24-hr moving averages. For individuals with COPD, interquartile range (IQR) increases in 4-hr ambient PM\(_{2.5}\) (11.65 μg/m\(^3\)) and nitrogen dioxide (11.97 ppb) were associated with 8.3% [95% confidence interval (CI), 1.7–15.3%] and 7.7% (95% CI, 0.1–15.9%) increase in the SD of normal R-R intervals (SDNN), respectively. For individuals with MI, IQR increases in 4-hr PM\(_{2.5}\) (8.54 μg/m\(^3\)) and NO2 (9.25 ppb) were associated with a nonsignificant 2.9% (95% CI, –7.8 to 2.3) and significant 12.1 (95% CI, –19.5 to –4.0) decrease in SDNN. Beta-blocker and bronchodilator intake and baseline forced expiratory volume in 1 sec modified the PM–SDNN association significantly, with effects consistent with those by disease group. Results indicate heterogeneity in the autonomic response to air pollution due to differences in baseline health, with significant associations for ambient NO2 suggesting an important role for traffic-related pollution. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi://10.1289/ehp.8337 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440781/pdf/ en_US
dash.license LAA
dc.subject ambient pollution en_US
dc.subject chronic obstructive pulmonary disease en_US
dc.subject fine particulate matter en_US
dc.subject heart rate variability en_US
dc.subject myocardial infarctions en_US
dc.subject nitrogen dioxide en_US
dc.title The Relationship Between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Disease en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Zanobetti, Antonella
dc.date.available 2012-02-12T05:05:49Z
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US

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