Show simple item record

dc.contributor.authorHu, Howard
dc.contributor.authorTéllez-Rojo, Martha María
dc.contributor.authorLamadrid-Figueroa, Héctor
dc.contributor.authorSchnaas, Lourdes
dc.contributor.authorMercado-García, Adriana
dc.contributor.authorHernández-Avila, Mauricio
dc.contributor.authorBellinger, David C.
dc.contributor.authorSmith, Donald
dc.contributor.authorEttinger, Adrienne S
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2012-02-13T18:06:35Z
dc.date.issued2006
dc.identifier.citationHu, Howard, Martha Mari­a Tellez-Rojo, David Bellinger, Donald Smith, Adrienne S. Ettinger, Hector Lamadrid-Figueroa, Joel Schwartz, Lourdes Schnaas, Adriana Mercado-Garci­a, and Mauricio Hernandez-Avila. 2006. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environmental Health Perspectives 114(11): 1730-1735.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8157299
dc.description.abstractBackground: The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. Objective: We studied prenatal lead exposure’s impact on neurodevelopment using repeated measures of fetal dose as reflected by maternal whole blood and plasma lead levels. Methods: We measured lead in maternal plasma and whole blood during each trimester in 146 pregnant women in Mexico City. We then measured umbilical cord blood lead at delivery and, when offspring were 12 and 24 months of age, measured blood lead and administered the Bayley Scales of Infant Development. We used multivariate regression, adjusting for covariates and 24-month blood lead, to compare the impacts of our pregnancy measures of fetal lead dose. Results: Maternal lead levels were moderately high with a first-trimester blood lead mean (± SD) value of 7.1 ± 5.1 μg/dL and 14% of values ≥10 μg/dL. Both maternal plasma and whole blood lead during the first trimester (but not in the second or third trimester) were significant predictors (p less than 0.05) of poorer Mental Development Index (MDI) scores. In models combining all three trimester measures and using standardized coefficients, the effect of first-trimester maternal plasma lead was somewhat greater than the effect of first-trimester maternal whole blood lead and substantially greater than the effects of second- or third-trimester plasma lead, and values averaged over all three trimesters. A 1-SD change in first-trimester plasma lead was associated with a reduction in MDI score of 3.5 points. Postnatal blood lead levels in the offspring were less strongly correlated with MDI scores. Conclusions: Fetal lead exposure has an adverse effect on neurodevelopment, with an effect that may be most pronounced during the first trimester and best captured by measuring lead in either maternal plasma or whole blood.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.9067en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665421/pdf/en_US
dash.licenseLAA
dc.subjectchildren's healthen_US
dc.subjectboneen_US
dc.subjectIQen_US
dc.subjectleaden_US
dc.subjectplasmaen_US
dc.subjectpregnancyen_US
dc.subjectneurodevelopmenten_US
dc.titleFetal Lead Exposure at Each Stage of Pregnancy as a Predictor of Infant Mental Developmenten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorBellinger, David C.
dc.date.available2012-02-13T18:06:35Z
dash.affiliation.otherHMS^Neurology-Children's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1289/ehp.9067*
dash.authorsorderedfalse
dash.contributor.affiliatedEttinger, Adrienne
dash.contributor.affiliatedBellinger, David
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record