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dc.contributor.authorHallatschek, Oskar
dc.contributor.authorNelson, David R.
dc.date.accessioned2012-02-13T19:13:35Z
dc.date.issued2010
dc.identifier.citationHallatschek, Oskar and David R. Nelson. 2010. Life at the front of an expanding population. Evolution 64(1): 193-206.en_US
dc.identifier.issn0014-3820en_US
dc.identifier.issn1558-5646en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160650
dc.description.abstractEnvironmental changes have caused episodes of habitat expansions in the evolutionary history of many species. These range changes affect the dynamics of biological evolution in multiple ways. Recent microbial experiments as well as simulations suggest that enhanced genetic drift at the frontier of a two-dimensional range expansion can cause genetic sectoring patterns with fractal domain boundaries. Here, we propose and analyze a simple model of asexual biological evolution at expanding frontiers that explains these neutral patterns and predicts the effect of natural selection. We find that beneficial mutations give rise to sectors with an opening angle that depends sensitively on the selective advantage of the mutants. Deleterious mutations, on the other hand, are not able to establish a sector permanently. They can, however, temporarily “surf” on the population front, and thereby reach unusually high frequencies. As a consequence, expanding frontiers are loaded with a high fraction of mutants at mutation–selection balance. Numerically, we also determine the condition at which the wild type is lost in favor of deleterious mutants (genetic meltdown) at a growing front. Our prediction for this error threshold differs qualitatively from existing well-mixed theories, and sets tight constraints on sustainable mutation rates for populations that undergo frequent range expansions.en_US
dc.description.sponsorshipPhysicsen_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1111/j.1558-5646.2009.00809.xen_US
dc.relation.hasversionhttp://arxiv.org/abs/0810.0053v2en_US
dash.licenseOAP
dc.subjectgenetic driften_US
dc.subjectgenetic loaden_US
dc.subjectneutral mutationen_US
dc.subjectrange expansionen_US
dc.subjectstepping stoneen_US
dc.titleLife at the Front of an Expanding Populationen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalEvolutionen_US
dash.depositing.authorNelson, David R.
dc.date.available2012-02-13T19:13:35Z
dc.identifier.doi10.1111/j.1558-5646.2009.00809.x*
dash.contributor.affiliatedNelson, David


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