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dc.contributor.authorShu, Xiao Ou
dc.contributor.authorLong, Jirong
dc.contributor.authorCai, Qiuyin
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorTai, E. Shyong
dc.contributor.authorLi, Xiangyang
dc.contributor.authorLin, Xu
dc.contributor.authorChow, Wong-Ho
dc.contributor.authorGo, Min Jin
dc.contributor.authorSeielstad, Mark
dc.contributor.authorLi, Huaixing
dc.contributor.authorYu, Kai
dc.contributor.authorWen, Wanqing
dc.contributor.authorShi, Jiajun
dc.contributor.authorHan, Bok-Ghee
dc.contributor.authorSim, Xue Ling
dc.contributor.authorLiu, Liegang
dc.contributor.authorKim, Hyung-Lae
dc.contributor.authorNg, Daniel P. K.
dc.contributor.authorLee, Jong-Young
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorVisscher, Peter M.
dc.contributor.authorQi, Lu
dc.contributor.authorCho, Yoon-Jae
dc.contributor.authorBao, Wei
dc.contributor.authorCornelis, Marilyn
dc.contributor.authorQi, Qibin
dc.contributor.authorKim, Young Jin
dc.contributor.authorLi, Chun
dc.contributor.authorZheng, Wei
dc.contributor.authorHu, Frank B.
dc.date.accessioned2012-02-13T20:48:00Z
dc.date.issued2010
dc.identifier.citationShu, Xiao Ou, Jirong Long, Qiuyin Cai, Lu Qi, Yong-Bing Xiang, Yoon Shin Cho, E. Shyong Tai, et al. 2010. Identification of new genetic risk variants for type 2 diabetes. PLoS Genetics 6(9): e1001127.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160723
dc.description.abstractAlthough more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, suggesting that the majority of inter-person genetic variation in this disease remains to be determined. We conducted a multistage, genome-wide association study (GWAS) within the Asian Consortium of Diabetes to search for T2D susceptibility markers. From 590,887 SNPs genotyped in 1,019 T2D cases and 1,710 controls selected from Chinese women in Shanghai, we selected the top 2,100 SNPs that were not in linkage disequilibrium (r\(^2\) less than 0.2) with known T2D loci for in silico replication in three T2D GWAS conducted among European Americans, Koreans, and Singapore Chinese. The 5 most promising SNPs were genotyped in an independent set of 1,645 cases and 1,649 controls from Shanghai, and 4 of them were further genotyped in 1,487 cases and 3,316 controls from 2 additional Chinese studies. Consistent associations across all studies were found for rs1359790 (13q31.1), rs10906115 (10p13), and rs1436955 (15q22.2) with P-values (per allele OR, 95%CI) of 6.49×10\(^{−9}\) (1.15, 1.10–1.20), 1.45×10\(^{−8}\) (1.13, 1.08–1.18), and 7.14×10\(^{−7}\) (1.13, 1.08–1.19), respectively, in combined analyses of 9,794 cases and 14,615 controls. Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1001127en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940731/pdf/en_US
dash.licenseLAA
dc.subjectgene discoveryen_US
dc.subjectgenetics of diseaseen_US
dc.subjectgenetics and genomicsen_US
dc.titleIdentification of New Genetic Risk Variants for Type 2 Diabetesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorQi, Lu
dc.date.available2012-02-13T20:48:00Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Nutritionen_US
dash.affiliation.otherSPH^Nutritionen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Nutritionen_US
dc.identifier.doi10.1371/journal.pgen.1001127*
dash.authorsorderedfalse
dash.contributor.affiliatedCornelis, Marilyn
dash.contributor.affiliatedZheng, Wei
dash.contributor.affiliatedCho, Yoon
dash.contributor.affiliatedQi, Qibin
dash.contributor.affiliatedQi, Lu
dash.contributor.affiliatedHu, Frank


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