dc.contributor.author | Mordukhovich, Irina | |
dc.contributor.author | Wilker, Elissa Hope | |
dc.contributor.author | Suh MacIntosh, Helen H. | |
dc.contributor.author | Wright, Robert O. | |
dc.contributor.author | Sparrow, David | |
dc.contributor.author | Vokonas, Pantel S | |
dc.contributor.author | Schwartz, Joel David | |
dc.date.accessioned | 2012-02-13T20:52:38Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Mordukhovich, Irina, Elissa Wilker, Helen Suh, Robert Wright, David Sparrow, Pantel S. Vokonas, and Joel Schwartz. 2009. Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study. Environmental Health Perspectives 117(11): 1767-1772. | en_US |
dc.identifier.issn | 0091-6765 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160725 | |
dc.description.abstract | Background: Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies have investigated the relationship between PM and BP and found mixed results. Evidence suggests that traffic-related air pollution contributes significantly to PM-related cardiovascular effects. Objectives: We hypothesized that black carbon (BC), a traffic-related combustion by-product, would be more strongly associated with BP than would fine PM [aerodynamic diameter ≤ 2.5 μm (PM\(_{2.5}\))], a heterogeneous PM mixture, and that these effects would be larger among participants with genetic variants associated with impaired antioxidative defense. Methods: We performed a repeated-measures analysis in elderly men to analyze associations between PM\(_{2.5}\) and BC exposure and BP using mixed-effects models with random intercepts, adjusting for potential confounders. We also examined statistical interaction between BC and genetic variants related to oxidative stress defense: GSTM1, GSTP1, GSTT1, NQO1, catalase, and HMOX-1. Results: A 1-SD increase in BC concentration was associated with a 1.5-mmHg increase in systolic BP [95% confidence interval (CI), 0.1–2.8] and a 0.9-mmHg increase in diastolic BP (95% CI, 0.2–1.6). We observed no evidence of statistical interaction between BC and any of the genetic variants examined and found no association between PM\(_{2.5}\) and BP. Conclusions: We observed positive associations between BP and BC, but not between BP and PM\(_{2.5}\), and found no evidence of effect modification of the association between BC and BP by gene variants related to antioxidative defense. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.isversionof | doi://10.1289/ehp.0900591 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801196/pdf/ | en_US |
dash.license | LAA | |
dc.subject | black carbon | en_US |
dc.subject | blood pressure | en_US |
dc.subject | epidemiology | en_US |
dc.subject | gene–environment interactions | en_US |
dc.subject | human | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | particulate matter | en_US |
dc.title | Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-measures Study | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Environmental Health Perspectives | en_US |
dash.depositing.author | Wilker, Elissa Hope | |
dc.date.available | 2012-02-13T20:52:38Z | |
dash.affiliation.other | SPH^Exposure Epidemiology and Risk Program | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Environmental+Occupational Medicine+Epi | en_US |
dash.affiliation.other | HMS^Pediatrics-Children's Hospital | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Exposure Epidemiology and Risk Program | en_US |
dc.identifier.doi | 10.1289/ehp.0900591 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Suh MacIntosh, Helen H. | |
dash.contributor.affiliated | Vokonas, Pantel | |
dash.contributor.affiliated | Wilker, Elissa | |
dash.contributor.affiliated | Wright, Robert | |
dash.contributor.affiliated | Sparrow, David | |
dash.contributor.affiliated | Schwartz, Joel | |
dc.identifier.orcid | 0000-0002-2557-150X | |