Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

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Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

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Title: Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys
Author: Sergeyev, Oleg; Lee, Mary M.; Revich, Boris; Patterson, Donald G.; Turner, Wayman E.; Needham, Larry L.; Saharov, Igor; Burns, Jane S; Williams, Paige L.; Korrick, Susan Abigail; Altshul, Lairsa; Hauser, Russ B.

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Citation: Burns, Jane S., Paige L. Williams, Oleg Sergeyev, Susan Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, et al. 2009. Predictors of serum dioxins and PCBs among peripubertal Russian boys. Environmental Health Perspectives 117(10): 1593-1599.
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Abstract: Background: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. Objectives: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. Methods: We used general linear regression models to explore associations of log10-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. Results: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived less than 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8–35.0] than boys who lived greater than 5 km away (adjusted mean = 18.8; 95% CI, 17.2–20.6). Conclusions: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.
Published Version: doi:10.1289/ehp.0800223
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790515/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160848
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