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dc.contributor.authorSergeyev, Oleg
dc.contributor.authorLee, Mary M.
dc.contributor.authorRevich, Boris
dc.contributor.authorPatterson, Donald G.
dc.contributor.authorTurner, Wayman E.
dc.contributor.authorNeedham, Larry L.
dc.contributor.authorSaharov, Igor
dc.contributor.authorBurns, Jane S
dc.contributor.authorWilliams, Paige L.
dc.contributor.authorKorrick, Susan Abigail
dc.contributor.authorAltshul, Lairsa
dc.contributor.authorHauser, Russ B.
dc.date.accessioned2012-02-14T00:11:52Z
dc.date.issued2009
dc.identifier.citationBurns, Jane S., Paige L. Williams, Oleg Sergeyev, Susan Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, et al. 2009. Predictors of serum dioxins and PCBs among peripubertal Russian boys. Environmental Health Perspectives 117(10): 1593-1599.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160848
dc.description.abstractBackground: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. Objectives: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. Methods: We used general linear regression models to explore associations of log10-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. Results: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived less than 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8–35.0] than boys who lived greater than 5 km away (adjusted mean = 18.8; 95% CI, 17.2–20.6). Conclusions: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.0800223en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790515/pdf/en_US
dash.licenseLAA
dc.subjectchildren's healthen_US
dc.subjectchildrenen_US
dc.subjectdieten_US
dc.subjectenvironmenten_US
dc.subjectepidemiologyen_US
dc.subjectpolychlorinated biphenylsen_US
dc.subjectpolychlorinated dibenzodioxinsen_US
dc.subjectpolychlorinated biphenyls, polychlorinated dibenzodioxins, polychlorinated dibenzofuransen_US
dc.titlePredictors of Serum Dioxins and PCBs among Peripubertal Russian Boysen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorHauser, Russ B.
dc.date.available2012-02-14T00:11:52Z
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dc.identifier.doi10.1289/ehp.0800223*
dash.authorsorderedfalse
dash.contributor.affiliatedBurns, Jane
dash.contributor.affiliatedKorrick, Susan
dash.contributor.affiliatedHauser, Russ
dash.contributor.affiliatedWilliams, Paige


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