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dc.contributor.authorCarrasco, Daniel R.
dc.contributor.authorSukhdeo, Kumar
dc.contributor.authorProtopopova, Marina
dc.contributor.authorEnos, Miriam
dc.contributor.authorZheng, Mei
dc.contributor.authorMani, Mala
dc.contributor.authorIvanova, Elena V.
dc.contributor.authorTonon, Giovanni
dc.contributor.authorSinha, Raktim
dc.contributor.authorCarrasco, Daniel E.
dc.contributor.authorHenderson, Joel Michael
dc.contributor.authorPinkus, Geraldine Sowinski
dc.contributor.authorMunshi, Nikhil C
dc.contributor.authorHorner, James W.
dc.contributor.authorProtopopov, Alexei
dc.contributor.authorAnderson, Kenneth Carl
dc.contributor.authorDePinho, Ronald A.
dc.date.accessioned2012-02-14T00:30:54Z
dc.date.issued2007
dc.identifier.citationCarrasco, Daniel R., Kumar Sukhdeo, Marina Protopopova, Raktim Sinha, Miriam Enos, Daniel E. Carrasco, Mei Zheng, et al. 2007. The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis. Cancer Cell 11(4): 349-360.en_US
dc.identifier.issn1535-6108en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160855
dc.description.abstractMultiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Eμ-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing unfolded protein/ER stress response and plasma-cell development. Eμ-XBP-1s elicited elevated serum Ig and skin alterations. With age, Eμ-xbp-1s transgenics develop features diagnostic of human MM, including bone lytic lesions and subendothelial Ig deposition. Furthermore, transcriptional profiles of Eμ-xbp-1s lymphoid and MM cells show aberrant expression of known human MM dysregulated genes. The similarities of this model with the human disease, coupled with documented frequent XBP-1s overexpression in human MM, serve to implicate XBP-1s dysregulation in MM pathogenesis.en_US
dc.language.isoen_USen_US
dc.publisherCell Pressen_US
dc.relation.isversionofdoi:10.1016/j.ccr.2007.02.015en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885943/pdf/en_US
dash.licenseLAA
dc.subjectcell cycleen_US
dc.titleThe Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCancer Cellen_US
dash.depositing.authorPinkus, Geraldine Sowinski
dc.date.available2012-02-14T00:30:54Z
dash.affiliation.otherHMS^Pathologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1016/j.ccr.2007.02.015*
dash.authorsorderedfalse
dash.contributor.affiliatedSinha, Raktim
dash.contributor.affiliatedHorner, James W.
dash.contributor.affiliatedPinkus, Geraldine
dash.contributor.affiliatedHenderson, Joel
dash.contributor.affiliatedProtopopov, Alexei
dash.contributor.affiliatedMunshi, Nikhil
dash.contributor.affiliatedDePinho, Ronald A.
dash.contributor.affiliatedAnderson, Kenneth


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