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dc.contributor.authorPorter, Stacy Ann
dc.contributor.authorMassaro, Joseph M.
dc.contributor.authorHoffmann, Udo
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorO'Donnel, Christopher J.
dc.contributor.authorFox, Caroline
dc.date.accessioned2012-02-14T00:45:11Z
dc.date.issued2009
dc.identifier.citationPorter, Stacy A., Joseph M. Massaro, Udo Hoffmann, Ramachandran S. Vasan, Christopher J. O'Donnel, and Caroline S. Fox. 2009. Abdominal subcutaneous adipose tissue: A protective fat depot? Diabetes Care 32, no. 6: 1068-1075.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160860
dc.description.abstractOBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN AND METHODS: Participants from the Framingham Heart Study (n = 3,001, 48.5% women) were stratified by visceral adipose tissue (VAT) into sex-specific tertiles. Within these tertiles, age-adjusted abdominal subcutaneous adipose tissue (SAT) tertiles were examined in relation to cardiometabolic risk factors. RESULTS: In the lowest VAT tertile, risk factor prevalence was low, although systolic blood pressure in women and rates of high triglycerides, impaired fasting glucose, hypertension, and the metabolic syndrome in men increased with increasing SAT tertile (all P < 0.04). In contrast, in the top VAT tertile, lower triglycerides were observed in men with increasing SAT (64.4% high triglycerides in SAT tertile 1 vs. 52.7% in SAT tertile 3, P = 0.03). Similar observations were made for women, although results were not statistically significant (50.6% high triglycerides in SAT tertile 1 vs. 41.0% in tertile 3, P = 0.10). Results in the highest VAT tertile were notable for a lack of increase in the prevalence of low HDL in men and women and in rates of impaired fasting glucose in men with increasing subcutaneous fat, despite sizable differences in BMI across SAT tertiles (27.1 to 36.3 kg/m\(^2\) [women]; 28.1 to 35.7 kg/m\(^2\) [men]). CONCLUSIONS: Although adiposity increases the absolute risk of metabolic and cardiovascular disease, abdominal subcutaneous fat is not associated with a linear increase in the prevalence of all risk factors among the obese, most notably, high triglycerides.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi://10.2337/dc08-2280en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681034/pdf/en_US
dash.licenseLAA
dc.titleAbdominal Subcutaneous Adipose Tissue: A Protective Fat Depot?en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetes Careen_US
dash.depositing.authorHoffmann, Udo
dc.date.available2012-02-14T00:45:11Z
dash.affiliation.otherHMS^Stipendees - Enrichment Programs Stipen_US
dash.affiliation.otherHMS^Radiology-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.2337/dc08-2280*
dash.contributor.affiliatedPorter, Stacy Ann
dash.contributor.affiliatedFox, Caroline
dash.contributor.affiliatedHoffmann, Udo


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