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dc.contributor.authorRich, David Q.
dc.contributor.authorMittleman, Murray A.
dc.contributor.authorLink, Mark S.
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorLuttmann-Gibson, Heike
dc.contributor.authorCatalano, Paul J.
dc.contributor.authorSpeizer, Frank Erwin
dc.contributor.authorGold, Diane R.
dc.contributor.authorDockery, Douglas W.
dc.date.accessioned2012-02-14T01:06:37Z
dc.date.issued2006
dc.identifier.citationRich, David Q., Murray A. Mittleman, Mark S. Link, Joel Schwartz, Heike Luttmann-Gibson, Paul J. Catalano, Frank E. Speizer, Diane R. Gold, and Douglas W. Dockery. 2006. Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution. Environmental Health Perspectives 114(1): 120-123.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160867
dc.description.abstractObjectives: We reported previously that 24-hr moving average ambient air pollution concentrations were positively associated with ventricular arrhythmias detected by implantable cardioverter defibrillators (ICDs). ICDs also detect paroxysmal atrial fibrillation episodes (PAF) that result in rapid ventricular rates. In this same cohort of ICD patients, we assessed the association between ambient air pollution and episodes of PAF. Design: We performed a case–crossover study. Participants: Patients who lived in the Boston, Massachusetts, metropolitan area and who had ICDs implanted between June 1995 and December 1999 (n = 203) were followed until July 2002. Evaluations/Measurements: We used conditional logistic regression to explore the association between community air pollution and 91 electrophysiologist-confirmed episodes of PAF among 29 subjects. Results: We found a statistically significant positive association between episodes of PAF and increased ozone concentration (22 ppb) in the hour before the arrhythmia (odds ratio = 2.08; 95% confidence interval = 1.22, 3.54; p = 0.001). The risk estimate for a longer (24-hr) moving average was smaller, thus suggesting an immediate effect. Positive but not statistically significant risks were associated with fine particles, nitrogen dioxide, and black carbon. Conclusions: Increased ambient O\(_3\) pollution was associated with increased risk of episodes of rapid ventricular response due to PAF, thereby suggesting that community air pollution may be a precipitant of these events.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.8371en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1332666/pdf/en_US
dash.licenseLAA
dc.subjectenvironmental medicineen_US
dc.subjectair pollutionen_US
dc.subjectarrhythmiasen_US
dc.subjectfibrillationen_US
dc.subjectepidemiologyen_US
dc.subjectcase–crossoveren_US
dc.subjectozoneen_US
dc.titleIncreased Risk of Paroxysmal Atrial Fibrillation Episodes Associated with Acute Increases in Ambient Air Pollutionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorMittleman, Murray A.
dc.date.available2012-02-14T01:06:37Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Program-EEen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherSPH^Environmental Healthen_US
dc.identifier.doi10.1289/ehp.8371*
dash.contributor.affiliatedSpeizer, Frank
dash.contributor.affiliatedGold, Diane
dash.contributor.affiliatedCatalano, Paul
dash.contributor.affiliatedDockery, Douglas
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedMittleman, Murray
dc.identifier.orcid0000-0002-2557-150X


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