Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis

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Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis

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Title: Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis
Author: Qureshi, Muddasir; Brown Jr, Robert H; Rogers, Jack Timothy; Cudkowicz, Merit Ester

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Citation: Qureshi, Muddasir, Robert H Brown Jr, Jack T Rogers, and Merit E Cudkowicz. 2008. Serum Ferritin and Metal Levels as Risk Factors for Amyotrophic Lateral Sclerosis. The Open Neurology Journal 2: 51-54.
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Abstract: Metal toxicity has been identified as a possible risk factor for amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. We conducted a retrospective chart review of urinary, hair and blood metal levels and serum ferritin in 321 people with ALS seen over a ten-year period at the Massachusetts General Hospital (MGH). We found that hair lead levels and serum ferritin levels were elevated in ALS patients compared to published normal values. Metal levels of arsenic, lead, mercury, cadmium, thallium, cobalt and aluminum in 24-hour urine specimens and lead, mercury and arsenic in serum were within the normal range. We conclude that twenty-four hour urine or blood testing for metals is not warranted as part of the evaluation of ALS. Elevated levels of serum ferritin in ALS population could reflect an underlying perturbation in iron metabolism.
Published Version: doi://10.2174/1874205X00802010051
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627516/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160869
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