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dc.contributor.authorQiu, Runxiang
dc.contributor.authorWang, Xiuyun
dc.contributor.authorDavy, Alice
dc.contributor.authorWu, Chen
dc.contributor.authorMurai, Kiyohito
dc.contributor.authorZhang, Heying
dc.contributor.authorFlanagan, John Gerard
dc.contributor.authorSoriano, Philippe
dc.contributor.authorLu, Qiang
dc.date.accessioned2012-02-14T01:33:08Z
dc.date.issued2008
dc.identifier.citationQiu, Runxiang, Xiuyun Wang, Alice Davy, Chen Wu, Kiyohito Murai, Heying Zhang, John G. Flanagan, Philippe Soriano, and Qiang Lu. 2008. Regulation of neural progenitor cell state by ephrin-B. The Journal of Cell Biology 181(6): 973-983.en_US
dc.identifier.issn0021-9525en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8160871
dc.description.abstractMaintaining a balance between self-renewal and differentiation in neural progenitor cells during development is important to ensure that correct numbers of neural cells are generated. We report that the ephrin-B–PDZ-RGS3 signaling pathway functions to regulate this balance in the developing mammalian cerebral cortex. During cortical neurogenesis, expression of ephrin-B1 and PDZ-RGS3 is specifically seen in progenitor cells and is turned off at the onset of neuronal differentiation. Persistent expression of ephrin-B1 and PDZ-RGS3 prevents differentiation of neural progenitor cells. Blocking RGS-mediated ephrin-B1 signaling in progenitor cells through RNA interference or expression of dominant-negative mutants results in differentiation. Genetic knockout of ephrin-B1 causes early cell cycle exit and leads to a concomitant loss of neural progenitor cells. Our results indicate that ephrin-B function is critical for the maintenance of the neural progenitor cell state and that this role of ephrin-B is mediated by PDZ-RGS3, likely via interacting with the noncanonical G protein signaling pathway, which is essential in neural progenitor asymmetrical cell division.en_US
dc.language.isoen_USen_US
dc.publisherThe Rockefeller University Pressen_US
dc.relation.isversionofdoi://10.1083/jcb.200708091en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426945/pdf/en_US
dash.licenseLAA
dc.titleRegulation of Neural Progenitor Cell State by Ephrin-Ben_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe Journal of Cell Biologyen_US
dash.depositing.authorFlanagan, John Gerard
dc.date.available2012-02-14T01:33:08Z
dash.affiliation.otherHMS^Cell Biologyen_US
dc.identifier.doi10.1083/jcb.200708091*
dash.contributor.affiliatedFlanagan, John


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