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dc.contributor.authorLee, Eunsung
dc.contributor.authorKamlet, Adam Seth
dc.contributor.authorPowers, David C.
dc.contributor.authorNeumann, Constanze Nicole
dc.contributor.authorBoursalian, Gregory Bagrad
dc.contributor.authorFuruya, Takeru
dc.contributor.authorChoi, Daniel C.
dc.contributor.authorHooker, Jacob M.
dc.contributor.authorRitter, Tobias
dc.date.accessioned2012-02-17T20:38:00Z
dc.date.issued2011
dc.identifier.citationLee, Eunsung, Adam Seth Kamlet, David C. Powers, Constanze Nicole Neumann, Gregory Bagrad Boursalian, Takeru Furuya, Daniel C. Choi, Jacob M. Hooker, and Tobias Ritter. 2011. A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging. Science 334(6056): 639-642.en_US
dc.identifier.issn0036-8075en_US
dc.identifier.issn1095-9203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8187682
dc.description.abstractThe unnatural isotope fluorine-18 \((^{18}F)\) is used as a positron emitter in molecular imaging. Currently, many potentially useful \(^{18}F\)-labeled probe molecules are inaccessible for imaging because no fluorination chemistry is available to make them. The 110-minute half-life of \(^{18}F\) requires rapid syntheses for which \([^{18}F]\)fluoride is the preferred source of fluorine because of its practical access and suitable isotope enrichment. However, conventional \([^{18}F]\)fluoride chemistry has been limited to nucleophilic fluorination reactions. We report the development of a palladium-based electrophilic fluorination reagent derived from fluoride and its application to the synthesis of aromatic \(^{18}F\)-labeled molecules via late-stage fluorination. Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.isversionofdoi:10.1126/science.1212625en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/22053044en_US
dash.licenseOAP
dc.subjectchemistryen_US
dc.subjectfluoridesen_US
dc.subjectfluorine radioisotopesen_US
dc.subjecthalogenationen_US
dc.subjectreagentsen_US
dc.subjectindicatorsen_US
dc.subjectchemical synthesisen_US
dc.subjectorganometallic compoundsen_US
dc.subjectpalladiumen_US
dc.subjectpositron-emission tomographyen_US
dc.titleA Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imagingen_US
dc.typeJournal Articleen_US
dc.description.versionAuthor's Originalen_US
dc.relation.journalScienceen_US
dash.depositing.authorRitter, Tobias
dc.date.available2012-02-17T20:38:00Z
dash.affiliation.otherAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical Schoolen_US
dc.identifier.doi10.1126/science.1212625*
dash.contributor.affiliatedBoursalian, Gregory
dash.contributor.affiliatedNeumann, Constanze N.
dash.contributor.affiliatedKamlet, Adam Seth
dash.contributor.affiliatedLee, Eunsung
dash.contributor.affiliatedRitter, Tobias
dash.contributor.affiliatedHooker, Jacob


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