Show simple item record

dc.contributor.authorXu, Yong
dc.contributor.authorJones, Juli E.
dc.contributor.authorKohno, Daisuke
dc.contributor.authorWilliams, Kevin W.
dc.contributor.authorChoi, Michelle J.
dc.contributor.authorAnderson, Jason G.
dc.contributor.authorHeisler, Lora K.
dc.contributor.authorZigman, Jeffrey M.
dc.contributor.authorElmquist, Joel K.
dc.contributor.authorLee, Charlotte E.
dc.contributor.authorLowell, Bradford Barr
dc.date.accessioned2012-02-19T23:27:56Z
dc.date.issued2008
dc.identifier.citationXu, Yong, Juli E. Jones, Daisuke Kohno, Kevin W. Williams, Charlotte E. Lee, Michelle J. Choi, Jason G. Anderson, et al. 2008. 5-HT\(_{\text{2C}}\)Rs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 60(4): 582-589.en_US
dc.identifier.issn0896-6273en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8191178
dc.description.abstractDrugs activating 5-hydroxytryptamine 2C receptors (5-HT\(_{\text{2C}}\)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT\(_{\text{2C}}\)Rs deficiency (2C null) and mice with 5-HT\(_{\text{2C}}\)Rs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). We show that 2C null mice predictably developed hyperphagia, hyperactivity, and obesity and showed attenuated responses to anorexigenic 5-HT drugs. Remarkably, all these deficiencies were normalized in 2C/POMC mice. These results demonstrate that 5-HT\(_{\text{2C}}\)R expression solely in POMC neurons is sufficient to mediate effects of serotoninergic compounds on food intake. The findings also highlight the physiological relevance of the 5-HT\(_{\text{2C}}\)R-melanocortin circuitry in the long-term regulation of energy balance.en_US
dc.language.isoen_USen_US
dc.publisherCell Pressen_US
dc.relation.isversionofdoi:10.1016/j.neuron.2008.09.033en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631191/pdf/en_US
dash.licenseMETA_ONLY
dc.subjecthumdiseaseen_US
dc.subjectmolneuroen_US
dc.subjectsignalingen_US
dc.title5-HT\(_{\text{2C}}\)Rs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNeuronen_US
dash.depositing.authorLowell, Bradford Barr
dash.embargo.until10000-01-01
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dc.identifier.doi10.1016/j.neuron.2008.09.033*
dash.authorsorderedfalse
dash.contributor.affiliatedLowell, Bradford


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record