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dc.contributor.authorBennett, Diane E.
dc.contributor.authorCamacho, Ricardo J.
dc.contributor.authorOtelea, Dan
dc.contributor.authorFleury, Hervé
dc.contributor.authorKiuchi, Mark
dc.contributor.authorHeneine, Walid
dc.contributor.authorKantor, Rami
dc.contributor.authorJordan, Michael R.
dc.contributor.authorSchapiro, Jonathan M.
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorSandstrom, Paul
dc.contributor.authorvan de Vijver, David
dc.contributor.authorRhee, Soo-Yon
dc.contributor.authorLiu, Tommy F.
dc.contributor.authorPillay, Deenan
dc.contributor.authorShafer, Robert W.
dc.contributor.authorKuritzkes, Daniel Robert
dc.contributor.authorBoucher, Charles Allen
dc.date.accessioned2012-02-25T01:57:49Z
dc.date.issued2009
dc.identifier.citationBennett, Diane E., Ricardo J. Camacho, Dan Otelea, Daniel R. Kuritzkes, Hervé Fleury, Mark Kiuchi, Walid Heneine, et al. 2009. Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update. PLoS ONE 4(3): e4724.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8255742
dc.description.abstractPrograms that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately compare transmitted drug resistance rates across geographic regions and times, the World Health Organization has recommended the adoption of a consensus genotypic definition of transmitted HIV-1 drug resistance. In January 2007, we outlined criteria for developing a list of mutations for drug-resistance surveillance and compiled a list of 80 RT and protease mutations meeting these criteria (surveillance drug resistance mutations; SDRMs). Since January 2007, several new drugs have been approved and several new drug-resistance mutations have been identified. In this paper, we follow the same procedures described previously to develop an updated list of SDRMs that are likely to be useful for ongoing and future studies of transmitted drug resistance. The updated SDRM list has 93 mutations including 34 NRTI-resistance mutations at 15 RT positions, 19 NNRTI-resistance mutations at 10 RT positions, and 40 PI-resistance mutations at 18 protease positions.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0004724en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648874/pdf/en_US
dash.licenseLAA
dc.subjectinfectious diseasesen_US
dc.subjectantimicrobials and drug resistanceen_US
dc.subjectHIV infection and AIDSen_US
dc.subjectpublic health and epidemiologyen_US
dc.subjectepidemiologyen_US
dc.titleDrug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Updateen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorKuritzkes, Daniel Robert
dc.date.available2012-02-25T01:57:49Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0004724*
dash.authorsorderedfalse
dash.contributor.affiliatedBoucher, Charles
dash.contributor.affiliatedKuritzkes, Daniel


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