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dc.contributor.authorLacson, Ronilda C.
dc.contributor.authorMbagwu, Michael
dc.contributor.authorYousif, Hisham
dc.contributor.authorOhno-Machado, Lucila
dc.date.accessioned2012-02-25T02:27:40Z
dc.date.issued2010
dc.identifier.citationLacson, Ronilda, Michael Mbagwu, Hisham Yousif, and Lucila Ohno-Machado. 2010. Assessing the quality of annotations in asthma gene expression experiments. BMC Bioinformatics 11(Suppl 9): S8.en_US
dc.identifier.issn1471-2105en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8255746
dc.description.abstractBackground: The amount of data deposited in the Gene Expression Omnibus (GEO) has expanded significantly. It is important to ensure that these data are properly annotated with clinical data and descriptions of experimental conditions so that they can be useful for future analysis. This study assesses the adequacy of documented asthma markers in GEO. Three objective measures (coverage, consistency and association) were used for evaluation of annotations contained in 17 asthma studies. Results: There were 918 asthma samples with 20,640 annotated markers. Of these markers, only 10,419 had documented values (50% coverage). In one study carefully examined for consistency, there were discrepancies in drug name usage, with brand name and generic name used in different sections to refer to the same drug. Annotated markers showed adequate association with other relevant variables (i.e. the use of medication only when its corresponding disease state was present). Conclusions: There is inadequate variable coverage within GEO and usage of terms lacks consistency. Association between relevant variables, however, was adequate.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1471-2105-11-S9-S8en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967749/pdf/en_US
dash.licenseLAA
dc.titleAssessing the Quality of Annotations in Asthma Gene Expression Experimentsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Bioinformaticsen_US
dash.depositing.authorLacson, Ronilda C.
dc.date.available2012-02-25T02:27:40Z
dash.affiliation.otherHMS^Radiology-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1186/1471-2105-11-S9-S8*
dash.contributor.affiliatedLacson, Ronilda


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