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dc.contributor.authorMotion, J. P. Michael
dc.contributor.authorHuynh, Grace H.
dc.contributor.authorSzoka, Francis C.
dc.contributor.authorSiegel, Ronald D.
dc.date.accessioned2012-03-01T01:16:21Z
dc.date.issued2010
dc.identifier.citationMotion, J. P. Michael, Grace H. Huynh, Francis C. Szoka, and Ronald A. Siegel. 2010. Convection and retro-convection enhanced delivery: Some theoretical considerations related to drug targeting. Pharmaceutical Research 28(3): 472-479.en_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8296042
dc.description.abstractDelivery of drugs and macromolecules into the brain is a challenging problem, due in part to the blood–brain barrier. In this article, we focus on the possibilities and limitations of two infusion techniques devised to bypass the blood–brain barrier: convection enhanced delivery (CED) and retro-convection enhanced delivery (R-CED). CED infuses fluid directly into the interstitial space of brain or tumor, whereas R-CED removes fluid from the interstitial space, which results in the transfer of drugs from the vascular compartment into the brain or tumor. Both techniques have shown promising results for the delivery of drugs into large volumes of tissue. Theoretical approaches of varying complexity have been developed to better understand and predict brain interstitial pressures and drug distribution for these techniques. These theoretical models of flow and diffusion can only be solved explicitly in simple geometries, and spherical symmetry is usually assumed for CED, while axial symmetry has been assumed for R-CED. This perspective summarizes features of these models and provides physical arguments and numerical simulations to support the notion that spherical symmetry is a reasonable approximation for modeling CED and R-CED. We also explore the potential of multi-catheter arrays for delivering and compartmentalizing drugs using CED and R-CED.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Verlagen_US
dc.relation.isversionofdoi:10.1007/s11095-010-0296-2en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044083/pdf/en_US
dash.licenseMETA_ONLY
dc.subjectblood brain barrieren_US
dc.subjectconvection enhanced deliveryen_US
dc.subjectfinite element analysisen_US
dc.subjectmathematical modelen_US
dc.subjectretroconvection enhanced deliveryen_US
dc.titleConvection and Retro-Convection Enhanced Delivery: Some Theoretical Considerations Related to Drug Targetingen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPharmaceutical Researchen_US
dash.depositing.authorSiegel, Ronald D.
dash.embargo.until10000-01-01
dash.affiliation.other100162en_US
dc.identifier.doi10.1007/s11095-010-0296-2*
dash.contributor.affiliatedSiegel, Ronald


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