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dc.contributor.authorTang, Yanyan
dc.contributor.authorPan, Haihua
dc.contributor.authorXu, Xurong
dc.contributor.authorTang, Ruikang
dc.contributor.authorWang, Ben
dc.contributor.authorLiu, Peng
dc.date.accessioned2012-03-10T02:17:51Z
dc.date.issued2010
dc.identifier.citationWang, Ben, Peng Liu, Yanyan Tang, Haihua Pan, Xurong Xu, and Ruikang Tang. 2010. Guarding Embryo Development of Zebrafish by Shell Engineering: A Strategy to Shield Life from Ozone Depletion. PLoS ONE 5(4): e9963.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8347339
dc.description.abstractBackground: The reduced concentration of stratospheric ozone results in an increased flux of biologically damaging mid-ultraviolet radiation (UVB, 280 to 320 nm) reaching earth surfaces. Environmentally relevant levels of UVB negatively impact various natural populations of marine organisms, which is ascribed to suppressed embryonic development by increased radiation. Methodology/Principal Findings: Inspired by strategies in the living systems generated by evolution, we induce an extra UVB-adsorbed coat on the chorion (eggshell surrounding embryo) of zebrafish, during the blastula period. Short and long UV exposure experiments show that the artificial mineral-shell reduces the UV radiation effectively and the enclosed embryos become more robust. In contrast, the uncoated embryos cannot survive under the enhanced UVB condition. Conclusions: We suggest that an engineered shell of functional materials onto biological units can be developed as a strategy to shield lives to counteract negative changes of global environment, or to provide extra protection for the living units in biological research.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0009963en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848599/pdf/en_US
dash.licenseLAA
dc.subjectbiotechnologyen_US
dc.subjectbioengineeringen_US
dc.subjectchemical biologyen_US
dc.subjectbioinorganic chemistryen_US
dc.subjectbiomimetic chemistryen_US
dc.subjectchemistryen_US
dc.subjectphysical, inorganic, and analytical chemistryen_US
dc.titleGuarding Embryo Development of Zebrafish by Shell Engineering: A Strategy to Shield Life from Ozone Depletionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorWang, Ben
dc.date.available2012-03-10T02:17:51Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0009963*
dash.authorsorderedfalse
dash.contributor.affiliatedWang, Ben


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