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dc.contributor.authorDahlem, Markus A.
dc.contributor.authorHadjikhani, Nouchine
dc.date.accessioned2012-03-29T18:18:16Z
dc.date.issued2009
dc.identifier.citationDahlem, Markus A., and Nouchine Hadjikhani. 2009. Migraine Aura: Retracting Particle-Like Waves in Weakly Susceptible Cortex. PLoS ONE 4(4): e5007.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8462362
dc.description.abstractCortical spreading depression (SD) has been suggested to underlie migraine aura. Despite a precise match in speed, the spatio-temporal patterns of SD observed in animal cortex and aura symptoms mapped to the cortical surface ordinarily differ in aspects of size and shape. We show that this mismatch is reconciled by utilizing that both pattern types bifurcate from an instability point of generic reaction-diffusion models. To classify these spatio-temporal pattern we suggest a susceptibility scale having the value σ = 1 at the instability point. We predict that human cortex is only weakly susceptible to SD (σ<1), and support this prediction by directly matching visual aura symptoms with anatomical landmarks using fMRI retinotopic mapping. Moreover, we use retinal SD to give a proof of concept of the existence of this instability point and describe how cortical susceptibility to SD must be adjusted for migraine drug testing. Close to the instability point at σ = 1 the dynamical repertoire of cortical tissue is increased. As a consequence, the picture of an engulfing SD that became paradigmatic for migraine with aura needs to be modified in most cases towards a more spatially confined pattern that remains within the originating major gyrus or sulcus. Furthermore, we discuss the resulting implications on migraine pharmacology that is hitherto tested in the regime (σ>1), and potentially silent aura occurring below a second bifurcation point at σ = 0 on the susceptible scale.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0005007en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659426/pdf/en_US
dash.licenseLAA
dc.subjectbiophysicsen_US
dc.subjecttheory and simulationen_US
dc.subjectmathematicsen_US
dc.subjectnonlinear dynamicsen_US
dc.subjectneuroscienceen_US
dc.subjecttheoretical neuroscienceen_US
dc.subjectphysiologyen_US
dc.subjectpattern formationen_US
dc.subjectneurological disordersen_US
dc.subjectheadacheen_US
dc.subjectneuroimagingen_US
dc.subjectpathologyen_US
dc.subjectpathophysiologyen_US
dc.subjectpharmacologyen_US
dc.subjectdrug developmenten_US
dc.subjectradiology and medical imagingen_US
dc.subjectmagnetic resonance imagingen_US
dc.titleMigraine Aura: Retracting Particle-Like Waves in Weakly Susceptible Cortexen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorHadjikhani, Nouchine
dc.date.available2012-03-29T18:18:16Z
dash.affiliation.otherHMS^Radiology-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dc.identifier.doi10.1371/journal.pone.0005007*
dash.contributor.affiliatedHadjikhani, Nouchine


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