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dc.contributor.authorWang, Jihua
dc.contributor.authorCao, Zanxia
dc.contributor.authorZhao, Liling
dc.contributor.authorLi, Shuqiang
dc.date.accessioned2012-04-01T16:11:01Z
dc.date.issued2011
dc.identifier.citationWang, Jihua, Zanxia Cao, Liling Zhao, and Shuqiang Li. 2011. Novel strategies for drug discovery based on intrinsically disordered proteins (IDPs). International Journal of Molecular Sciences 12(5): 3205-3219.en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8482889
dc.description.abstractIntrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as tumor, Parkinson disease, Alzheimer disease, diabetes, and so on. These disease-associated IDPs commonly play principal roles in the disease-associated protein-protein interaction networks. Most of them in the disease datasets have more interactants and hence the size of the disease-associated IDPs interaction network is simultaneously increased. For example, the tumor suppressor protein p53 is an intrinsically disordered protein and also a hub protein in the p53 interaction network; α-synuclein, an intrinsically disordered protein involved in Parkinson diseases, is also a hub of the protein network. The disease-associated IDPs may provide potential targets for drugs modulating protein-protein interaction networks. Therefore, novel strategies for drug discovery based on IDPs are in the ascendant. It is dependent on the features of IDPs to develop the novel strategies. It is found out that IDPs have unique structural features such as high flexibility and random coil-like conformations which enable them to participate in both the “one to many” and “many to one” interaction. Accordingly, in order to promote novel strategies for drug discovery, it is essential that more and more features of IDPs are revealed by experimental and computing methods.en_US
dc.language.isoen_USen_US
dc.publisherMolecular Diversity Preservation Internationalen_US
dc.relation.isversionofdoi:10.3390/ijms12053205en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116186/en_US
dash.licenseLAA
dc.subjectintrinsically disordered proteinsen_US
dc.subjectsequence characterizationsen_US
dc.subjectstructural characterizationsen_US
dc.subjectinteraction networksen_US
dc.subjectdrug-discoveryen_US
dc.titleNovel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs)en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalInternational Journal of Molecular Sciencesen_US
dash.depositing.authorLi, Shuqiang
dc.date.available2012-04-01T16:11:01Z
dash.affiliation.other103562en_US
dc.identifier.doi10.3390/ijms12053205*
dash.contributor.affiliatedLi, Shuqiang


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