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dc.contributor.authorMordukhovich, Irina
dc.contributor.authorWright, Robert O.
dc.contributor.authorHu, Howard
dc.contributor.authorAmarasiriwardena, Chitra J.
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorLitonjua, Augusto Ampil
dc.contributor.authorSparrow, David
dc.contributor.authorVokonas, Pantel S
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2012-04-17T19:23:46Z
dc.date.issued2012
dc.identifier.citationMordukhovich, Irina, Robert O. Wright, Howard Hu, Chitra Amarasiriwardena, Andrea Baccarelli, Augusto Litonjua, David Sparrow, Pantel Vokonas, and Joel Schwartz. 2012. Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study. Environmental Health Perspectives 120(1): 98-104.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8589347
dc.description.abstractBackground: Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts.: Objectives: We hypothesized that chronic arsenic, cadmium, mercury, and lead exposures elevate BP and that manganese lowers BP.: Methods: We conducted a cross-sectional analysis of associations between toenail metals and BP among older men from the Normative Aging Study (n = 639), using linear regression and adjusting for potential confounders. Results: An interquartile range increase in toenail arsenic was associated with higher systolic BP [0.93 mmHg; 95% confidence interval (CI): 0.25, 1.62] and pulse pressure (0.76 mmHg; 95% CI: 0.22, 1.30). Positive associations between arsenic and BP and negative associations between manganese and BP were strengthened in models adjusted for other toenail metals.: Conclusions: Our findings suggest associations between BP and arsenic and manganese. This may be of public health importance because of prevalence of both metal exposure and cardiovascular disease. Results should be interpreted cautiously given potential limitations of toenails as biomarkers of metal exposure.:en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.1002805en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261928/pdf/en_US
dash.licenseLAA
dc.titleAssociations of Toenail Arsenic, Cadmium, Mercury, Manganese, and Lead with Blood Pressure in the Normative Aging Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorWright, Robert O.
dc.date.available2012-04-17T19:23:46Z
dc.identifier.doi10.1289/ehp.1002805*
dash.contributor.affiliatedAmarasiriwardena, Chitra
dash.contributor.affiliatedWright, Robert
dash.contributor.affiliatedVokonas, Pantel
dash.contributor.affiliatedSparrow, David
dash.contributor.affiliatedLitonjua, Augusto A.
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedBaccarelli, Andrea


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