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dc.contributor.authorGoto, Atsushi
dc.contributor.authorSong, Yiqing
dc.contributor.authorChen, Brian H.
dc.contributor.authorManson, JoAnn Elisabeth
dc.contributor.authorBuring, Julie Elizabeth
dc.contributor.authorLiu, Simin
dc.date.accessioned2012-04-19T19:09:51Z
dc.date.issued2011
dc.identifier.citationGoto, Atsushi, Yiqing Song, Brian H. Chen, JoAnn E. Manson, Julie E. Buring, and Simin Liu. 2011. Coffee and caffeine consumption in relation to sex hormone–binding globulin and risk of type 2 diabetes in postmenopausal women. Diabetes 60(1): 269-275.en_US
dc.identifier.issn0012-1797en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8603151
dc.description.abstractOBJECTIVE: Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone–binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk. RESEARCH DESIGN AND METHODS: We conducted a case-control study nested in the prospective Women's Health Study (WHS). During a median follow-up of 10 years, 359 postmenopausal women with newly diagnosed type 2 diabetes were matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw. RESULTS: Caffeinated coffee was positively associated with SHBG but not with sex hormones. Multivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/l among women consuming ≥4 cups/day of caffeinated coffee and 23.0 nmol/l among nondrinkers (P for trend = 0.01). In contrast, neither decaffeinated coffee nor tea was associated with SHBG or sex hormones. The multivariable-adjusted odds ratio (OR) of type 2 diabetes for women consuming ≥4 cups/day of caffeinated coffee compared with nondrinkers was 0.47 (95% CI 0.23–0.94; P for trend = 0.047). The association was largely attenuated after further adjusting for SHBG (OR 0.71 [95% CI 0.31–1.61]; P for trend = 0.47). In addition, carriers of rs6259 minor allele and noncarriers of rs6257 minor allele of SHBG gene consuming ≥2 cups/day of caffeinated coffee had lower risk of type 2 diabetes in directions corresponding to their associated SHBG. CONCLUSIONS: Our findings suggest that SHBG may account for the inverse association between coffee consumption and type 2 diabetes risk among postmenopausal women.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/db10-1193en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012180/pdf/en_US
dash.licenseLAA
dc.subjectcomponentsen_US
dc.subjectkahweolen_US
dc.subjectcafestolen_US
dc.subjectraten_US
dc.subjectpremenopausalen_US
dc.subjectinductionen_US
dc.subjectestradiolen_US
dc.subjectmellitusen_US
dc.subjectalcoholen_US
dc.subjectenzymeen_US
dc.subjectteaen_US
dc.titleCoffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Womenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetesen_US
dash.depositing.authorBuring, Julie Elizabeth
dc.date.available2012-04-19T19:09:51Z
dc.identifier.doi10.2337/db10-1193*
dash.contributor.affiliatedSong, Yiqing
dash.contributor.affiliatedBuring, Julie
dash.contributor.affiliatedManson, JoAnn


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