SOX2 Expression Correlates with Lymph-node Metastases and Distant Spread in Right-sided Colon Cancer

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SOX2 Expression Correlates with Lymph-node Metastases and Distant Spread in Right-sided Colon Cancer

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Title: SOX2 Expression Correlates with Lymph-node Metastases and Distant Spread in Right-sided Colon Cancer
Author: Neumann, Jens; Bahr, Fiorina; Kriegl, Lydia; Engel, Jutta; Luque, Raquel Mejias; Gerhard, Markus; Kirchner, Thomas; Jung, Andreas; Horst, David Nicolai

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Citation: Neumann, Jens, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejias Luque, Markus Gerhard, Thomas Kirchner, and Andreas Jung. 2011. Sox2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer. BMC Cancer 11: 518.
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Abstract: Background: The transcription factor SOX2, which is involved in the induction of pluripotent stem cells and contributes to colorectal carcinogenesis, is associated with a poor prognosis in colon cancer (CC). Furthermore, SOX2 is a repressor of the transcriptional activity of β-catenin in vitro. Since the majority of CC develop via an activation of the Wnt/β-catenin signalling pathway, indicated by nuclear expression of β-catenin, we wanted to investigate the expression patterns of SOX2 and β-catenin and correlate them with the occurrence of lymph node and distant metastases as indicators of malignant progression. Methods: The expression of SOX2 and β-catenin was investigated in a case control study utilizing a matched pair collection (N = 114) of right-sided CCs with either corresponding distant metastases (N = 57) or without distant spread (N = 57) by applying immunohistochemistry. Results: Elevated protein expression of SOX2 significantly correlated with the presence of lymph node- (p = 0.006) and distant metastases (p = 0.022). Nuclear β-catenin expression correlated significantly only with distant metastases (p = 0.001). Less than 10% of cases showed a coexpression of high levels of β-catenin and SOX2. The positivity for both markers was also associated with a very high risk for lymph-node metastases (p = 0.007) and distant spread (p = 0.028). Conclusion: We demonstrated that increased expression of either SOX2 or nuclear β-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymph-node metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread.
Published Version: doi:10.1186/1471-2407-11-518
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267776/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8603489
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