A Bayesian Approach for Fast and Accurate Gene Tree Reconstruction

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A Bayesian Approach for Fast and Accurate Gene Tree Reconstruction

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Title: A Bayesian Approach for Fast and Accurate Gene Tree Reconstruction
Author: Rasmussen, Matthew D.; Kellis, Manolis

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Citation: Rasmussen, Matthew D. and Manolis Kellis. 2011. A Bayesian approach for fast and accurate gene tree reconstruction. Molecular Biology and Evolution 28(1): 273-290.
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Abstract: Recent sequencing and computing advances have enabled phylogenetic analyses to expand to both entire genomes and large clades, thus requiring more efficient and accurate methods designed specifically for the phylogenomic context. Here, we present SPIMAP, an efficient Bayesian method for reconstructing gene trees in the presence of a known species tree. We observe many improvements in reconstruction accuracy, achieved by modeling multiple aspects of evolution, including gene duplication and loss (DL) rates, speciation times, and correlated substitution rate variation across both species and loci. We have implemented and applied this method on two clades of fully sequenced species, 12 Drosophila and 16 fungal genomes as well as simulated phylogenies and find dramatic improvements in reconstruction accuracy as compared with the most popular existing methods, including those that take the species tree into account. We find that reconstruction inaccuracies of traditional phylogenetic methods overestimate the number of DL events by as much as 2–3-fold, whereas our method achieves significantly higher accuracy. We feel that the results and methods presented here will have many important implications for future investigations of gene evolution.
Published Version: doi:10.1093/molbev/msq189
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002250/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8605300
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