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dc.contributor.authorAbdullahi, Osman
dc.contributor.authorKarani, Angela
dc.contributor.authorTigoi, Caroline C.
dc.contributor.authorMugo, Daisy
dc.contributor.authorKungu, Stella
dc.contributor.authorWanjiru, Eva
dc.contributor.authorJomo, Jane
dc.contributor.authorMusyimi, Robert
dc.contributor.authorLipsitch, Marc
dc.contributor.authorScott, J. Anthony G.
dc.date.accessioned2012-04-20T18:22:36Z
dc.date.issued2012
dc.identifier.citationAbdullahi, Osman, Angela Karani, Caroline C. Tigoi, Daisy Mugo, Stella Kungu, Eva Wanjiru, Jane Jomo, Robert Musyimi, Marc Lipsitch, and J. Anthony G. Scott. 2012. The prevalence and risk factors for pneumococcal colonization of the nasopharynx among children in Kilifi District, Kenya. PLoS ONE 7(2): e30787.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8605321
dc.description.abstractBackground: Pneumococcal conjugate vaccines (PCV) reduce nasopharyngeal carriage of vaccine-serotype pneumococci but increase in the carriage of non-vaccine serotypes. We studied the epidemiology of carriage among children 3–59 months old before vaccine introduction in Kilifi, Kenya. Methods: In a rolling cross-sectional study from October 2006 to December 2008 we approached 3570 healthy children selected at random from the population register of the Kilifi Health and Demographic Surveillance System and 134 HIV-infected children registered at a specialist clinic. A single nasopharyngeal swab was transported in STGG and cultured on gentamicin blood agar. A single colony of pneumococcus was serotyped by Quellung reaction. Results: Families of 2840 children in the population-based sample and 99 in the HIV-infected sample consented to participate; carriage prevalence was 65.8% (95% CI, 64.0–67.5%) and 76% (95% CI, 66–84%) in the two samples, respectively. Carriage prevalence declined progressively with age from 79% at 6–11 months to 51% at 54–59 months (p<0.0005). Carriage was positively associated with coryza (Odds ratio 2.63, 95%CI 2.12–3.25) and cough (1.55, 95%CI 1.26–1.91) and negatively associated with recent antibiotic use (0.53 95%CI 0.34–0.81). 53 different serotypes were identified and 42% of isolates were of serotypes contained in the 10-valent PCV. Common serotypes declined in prevalence with age while less common serotypes did not. Conclusion: Carriage prevalence in children was high, serotypes were diverse, and the majority of strains were of serotypes not represented in the 10-valent PCV. Vaccine introduction in Kenya will provide a natural test of virulence for the many circulating non-vaccine serotypes.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0030787en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282706/pdf/en_US
dash.licenseLAA
dc.subjectHIVen_US
dc.subjectbiologyen_US
dc.subjectpopulation biologyen_US
dc.subjectepidemiologyen_US
dc.subjectmedicineen_US
dc.subjectinfectious diseasesen_US
dc.subjectbacterial diseasesen_US
dc.subjectviral diseasesen_US
dc.titleThe Prevalence and Risk Factors for Pneumococcal Colonization of the Nasopharynx among Children in Kilifi District, Kenyaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorLipsitch, Marc
dc.date.available2012-04-20T18:22:36Z
dc.identifier.doi10.1371/journal.pone.0030787*
dash.contributor.affiliatedAbdullahi, Osman
dash.contributor.affiliatedLipsitch, Marc


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