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dc.contributor.authorda Cruz, Filipa P.
dc.contributor.authorMartin, Cécilie
dc.contributor.authorLafuente-Monasterio, Maria J.
dc.contributor.authorRodrigues, Tiago
dc.contributor.authorSönnichsen, Birte
dc.contributor.authorMoreira, Rui
dc.contributor.authorGamo, Francisco-Javier
dc.contributor.authorHannus, Michael
dc.contributor.authorPrudêncio, Miguel
dc.contributor.authorBuchholz, Kathrin
dc.contributor.authorMarti, Matthias
dc.contributor.authorMota, Maria
dc.date.accessioned2012-04-20T19:46:34Z
dc.date.issued2012
dc.identifier.citationda Cruz, Filipa P., Cécilie Martin, Kathrin Buchholz, Maria J. Lafuente-Monasterio, Tiago Rodrigues, Birte Sönnichsen, Rui Moreira, et al. 2012. Drug screen targeted at plasmodium liver stages identifies a potent multistage antimalarial drug. The Journal of Infectious Diseases 205(8): 1278-1286.en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8605332
dc.description.abstractPlasmodium parasites undergo a clinically silent and obligatory developmental phase in the host’s liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds targeting the liver stage of malaria, we screened a library of 1037 existing drugs for their ability to inhibit Plasmodium hepatic development. Decoquinate emerged as the strongest inhibitor of Plasmodium liver stages, both in vitro and in vivo. Furthermore, decoquinate kills the parasite’s replicative blood stages and is active against developing gametocytes, the forms responsible for transmission. The drug acts by selectively and specifically inhibiting the parasite’s mitochondrial \(bc_1\) complex, with little cross-resistance with the antimalarial drug atovaquone. Oral administration of a single dose of decoquinate effectively prevents the appearance of disease, warranting its exploitation as a potent antimalarial compound.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isversionofdoi:10.1093/infdis/jis184en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308910/pdf/en_US
dash.licenseLAA
dc.subjectparasitesen_US
dc.titleDrug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drugen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe Journal of Infectious Diseasesen_US
dash.depositing.authorMota, Maria
dc.date.available2012-04-20T19:46:34Z
dc.identifier.doi10.1093/infdis/jis184*
dash.authorsorderedfalse
dash.contributor.affiliatedMota, Maria
dash.contributor.affiliatedBuchholz, Kathrin
dash.contributor.affiliatedMarti, Matthias


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