High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection

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High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection

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Title: High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection
Author: Michelow, Ian C.; Lear, Calli; Scully, Corinne; Prugar, Laura I.; Longley, Clifford B.; Yantosca, L. Michael; Ji, Xin; Karpel, Marshall; Brudner, Matthew; Spear, Gregory T.; Ezekowitz, R. Alan B.; Schmidt, Emmett V.; Olinger, Gene G.; Takahashi, Kazue

Note: Order does not necessarily reflect citation order of authors.

Citation: Michelow, Ian C., Calli Lear, Corinne Scully, Laura I. Prugar, Clifford B. Longley, L. Michael Yantosca, Xin Ji, et al. 2010. High-dose mannose-binding lectin therapy for ebola virus infection. Journal of Infectious Diseases 203(2): 175-179.
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Abstract: Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although recombinant human MBL (rhMBL) trials have focused on reconstitution therapy, safety studies have identified no barriers to its use at higher levels. Ebola viruses cause fatal hemorrhagic fevers for which no treatment exists and that are feared as potential biothreat agents. We found that mice whose rhMBL serum concentrations were increased ≥7-fold above average human levels survived otherwise fatal Ebola virus infections and became immune to virus rechallenge. Because Ebola glycoproteins potentially model other glycosylated viruses, rhMBL may offer a novel broad-spectrum antiviral approach.
Published Version: doi:10.1093/infdis/jiq025
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071052/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:8646758
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