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dc.contributor.authorDaniel, Carolin
dc.contributor.authorWeigmann, Benno
dc.contributor.authorBronson, Roderick Terry
dc.contributor.authorvon Boehmer, Harald
dc.date.accessioned2012-05-01T19:50:34Z
dc.date.issued2011
dc.identifier.citationDaniel, Carolin, Benno Weigmann, Roderick Bronson, and Harald von Boehmer. 2011. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. Journal of Experimental Medicine 208(7): 1501-1510.en_US
dc.identifier.issn0022-1007en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8646759
dc.description.abstractType 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A\(^{g7}\) molecules of nonobese diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex. Here, we describe a strongly agonistic insulin mimetope that effectively converts naive T cells into Foxp3\(^+\) regulatory T cells in vivo, thereby completely preventing T1D in NOD mice. In contrast, natural insulin epitopes are ineffective. Subimmunogenic vaccination with strongly agonistic insulin mimetopes might represent a novel strategy to prevent T1D in humans at risk for the disease.en_US
dc.language.isoen_USen_US
dc.publisherThe Rockefeller University Pressen_US
dc.relation.isversionofdoi:10.1084/jem.20110574en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135372/pdf/en_US
dash.licenseLAA
dc.titlePrevention of Type 1 Diabetes in Mice by Tolerogenic Vaccination with a Strong Agonist Insulin Mimetopeen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Experimental Medicineen_US
dash.depositing.authorDaniel, Carolin
dc.date.available2012-05-01T19:50:34Z
dc.identifier.doi10.1084/jem.20110574*
dash.contributor.affiliatedvon Boehmer, Harald
dash.contributor.affiliatedDaniel, Carolin
dash.contributor.affiliatedBronson, Roderick


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