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dc.contributor.authorDjebali, Sarah
dc.contributor.authorLagarde, Julien
dc.contributor.authorKapranov, Philipp
dc.contributor.authorLacroix, Vincent
dc.contributor.authorBorel, Christelle
dc.contributor.authorMudge, Jonathan M.
dc.contributor.authorHowald, Cédric
dc.contributor.authorFoissac, Sylvain
dc.contributor.authorUcla, Catherine
dc.contributor.authorChrast, Jacqueline
dc.contributor.authorRibeca, Paolo
dc.contributor.authorMurray, Ryan R.
dc.contributor.authorLin, Chenwei
dc.contributor.authorBell, Ian
dc.contributor.authorDumais, Erica
dc.contributor.authorDrenkow, Jorg
dc.contributor.authorTress, Michael L.
dc.contributor.authorGelpí, Josep Lluís
dc.contributor.authorOrozco, Modesto
dc.contributor.authorValencia, Alfonso
dc.contributor.authorvan Berkum, Nynke L.
dc.contributor.authorLajoie, Bryan R.
dc.contributor.authorStamatoyannopoulos, John
dc.contributor.authorBatut, Philippe
dc.contributor.authorDobin, Alex
dc.contributor.authorHarrow, Jennifer
dc.contributor.authorHubbard, Tim
dc.contributor.authorDekker, Job
dc.contributor.authorFrankish, Adam
dc.contributor.authorSalehi-Ashtiani, Kourosh
dc.contributor.authorReymond, Alexandre
dc.contributor.authorAntonarakis, Stylianos E.
dc.contributor.authorGuigó, Roderic
dc.contributor.authorGingeras, Thomas R.
dc.contributor.authorMartin, David
dc.contributor.authorYang, Xinping
dc.contributor.authorGhamsari, Lila
dc.contributor.authorVidal, Marc
dc.date.accessioned2012-05-01T20:00:05Z
dc.date.issued2012
dc.identifier.citationDjebali, Sarah, Julien Lagarde, Philipp Kapranov, Vincent Lacroix, Christelle Borel, Jonathan M. Mudge, Cédric Howald, et al. 2012. Evidence for transcript networks composed of chimeric rnas in human cells. PLoS ONE 7(1): e28213.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8646773
dc.description.abstractThe classic organization of a gene structure has followed the Jacob and Monod bacterial gene model proposed more than 50 years ago. Since then, empirical determinations of the complexity of the transcriptomes found in yeast to human has blurred the definition and physical boundaries of genes. Using multiple analysis approaches we have characterized individual gene boundaries mapping on human chromosomes 21 and 22. Analyses of the locations of the 5′ and 3′ transcriptional termini of 492 protein coding genes revealed that for 85% of these genes the boundaries extend beyond the current annotated termini, most often connecting with exons of transcripts from other well annotated genes. The biological and evolutionary importance of these chimeric transcripts is underscored by (1) the non-random interconnections of genes involved, (2) the greater phylogenetic depth of the genes involved in many chimeric interactions, (3) the coordination of the expression of connected genes and (4) the close in vivo and three dimensional proximity of the genomic regions being transcribed and contributing to parts of the chimeric RNAs. The non-random nature of the connection of the genes involved suggest that chimeric transcripts should not be studied in isolation, but together, as an RNA network.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0028213en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251577/pdf/en_US
dash.licenseLAA
dc.titleEvidence for Transcript Networks Composed of Chimeric RNAs in Human Cellsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorYang, Xinping
dc.date.available2012-05-01T20:00:05Z
dc.identifier.doi10.1371/journal.pone.0028213*
dash.authorsorderedfalse
dash.contributor.affiliatedGhamsari, Lila
dash.contributor.affiliatedYang, Xinping
dash.contributor.affiliatedVidal, Marc


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