Sirtuins, Metabolism, and Cancer
| Title: | Sirtuins, Metabolism, and Cancer |
| Author: |
Mostoslavsky, Raul; Martinez-Pastor, Barbara
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Martinez-Pastor, Barbara, and Raul Mostoslavsky. 2012. Sirtuins, Metabolism, and Cancer. Frontiers in Pharmacology 3: 22 |
| Full Text & Related Files: |
3282920.pdf (552.9Kb; PDF) 
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| Abstract: | More than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have been characterized, uncovering the underlying mechanisms of their multifaceted role in metabolism. Here, we specifically review recent progress on the role of sirtuins in DNA repair and energy metabolism, further discussing the implication of sirtuins in the biology of cancer. |
| Published Version: | doi://10.3389/fphar.2012.00022 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282920/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8704119 |
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