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dc.contributor.authorMartinez-Pastor, Barbara
dc.contributor.authorMostoslavsky, Raul
dc.date.accessioned2012-05-09T00:48:24Z
dc.date.issued2012
dc.identifier.citationMartinez-Pastor, Barbara, and Raul Mostoslavsky. 2012. Sirtuins, Metabolism, and Cancer. Frontiers in Pharmacology 3: 22en_US
dc.identifier.issn1663-9812en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8704119
dc.description.abstractMore than a decade ago, sirtuins were discovered as a highly conserved family of NAD+-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have been characterized, uncovering the underlying mechanisms of their multifaceted role in metabolism. Here, we specifically review recent progress on the role of sirtuins in DNA repair and energy metabolism, further discussing the implication of sirtuins in the biology of cancer.en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofdoi://10.3389/fphar.2012.00022en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282920/pdf/en_US
dash.licenseLAA
dc.subjectSIRT1en_US
dc.subjectSIRT6en_US
dc.subjectSIRT3en_US
dc.subjectWarburg effecten_US
dc.subjectcancer metabolismen_US
dc.subjectDNA repairen_US
dc.subjectgenomic instabilityen_US
dc.subjectsirtuin biologyen_US
dc.titleSirtuins, Metabolism, and Canceren_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalFrontiers in Pharmacologyen_US
dash.depositing.authorMostoslavsky, Raul
dc.date.available2012-05-09T00:48:24Z
dc.identifier.doi10.3389/fphar.2012.00022*
dash.contributor.affiliatedMostoslavsky, Raul


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