Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney

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Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney

Show simple item record Duah, Mary Staser, Karl Valerius, Michael Todd Hansard, Jennifer K. Guo, Jin-jin McMahon, Jill Ann Vaughan, Joseph E. Faria, Diane Georgas, Kylie Rumballe, Bree Ren, Qun Krautzberger, A. Michaela Junker, Jan P. Thiagarajan, Rathi D. Machanick, Philip Gray, Paul A. van Oudenaarden, Alexander Rowitch, David H. Stiles, Charles Dean Ma, Qiufu Grimmond, Sean M. Bailey, Timothy L. Little, Melissa H. McMahon, Andrew P. Yu, Jing 2012-05-11T19:42:05Z 2012
dc.identifier.citation Yu, Jing, Michael Todd Valerius, Mary Duah, Karl Staser, Jennifer K. Hansard, Jin-jin Guo, Jill Ann McMahon, et al. 2012. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 139(10): 1863-1873. en_US
dc.identifier.issn 0950-1991 en_US
dc.identifier.issn 1477-9129 en_US
dc.description.abstract Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cell type-specific transcriptional programs; consequently, transcriptional regulatory factors are useful markers of emerging cellular complexity, and their expression patterns provide insights into the regulatory mechanisms at play. We performed a comprehensive genome-scale in situ expression screen of 921 transcriptional regulators in the developing mammalian urogenital system. Focusing on the kidney, analysis of regional-specific expression patterns identified novel markers and cell types associated with development and patterning of the urinary system. Furthermore, promoter analysis of synexpressed genes predicts transcriptional control mechanisms that regulate cell differentiation. The annotated informational resource ( will facilitate functional analysis of the mammalian kidney and provides useful information for the generation of novel genetic tools to manipulate emerging cell populations. en_US
dc.description.sponsorship Stem Cell and Regenerative Biology en_US
dc.language.iso en_US en_US
dc.publisher Company of Biologists en_US
dc.relation.isversionof doi:10.1242/dev.074005 en_US
dc.relation.hasversion en_US
dash.license OAP
dc.subject genome-scale expression screen en_US
dc.subject transcriptional regulator en_US
dc.subject kidney en_US
dc.subject mouse en_US
dc.title Identification of Molecular Compartments and Genetic Circuitry in the Developing Mammalian Kidney en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Development en_US McMahon, Andrew P. 2012-05-11T19:42:05Z
dash.affiliation.other Department of Neurobiology en_US

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