Chiral Sulfinamide/Achiral Sulfonic Acid Cocatalyzed Enantioselective Protonation of Enol Silanes

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Beck, Elizabeth M.
Hyde, Alan M.
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https://doi.org/10.1021/ol201608aMetadata
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Beck, Elizabeth M., Alan M. Hyde, and Eric N. Jacbosen. 2011. Chiral sulfinamide/achiral sulfonic acid cocatalyzed enantioselective protonation of enol silanes. Organic Letters 13(16): 4260-4263.Abstract
The application of chiral sulfinamides and achiral sulfonic acids as a co-catalyst system for enantioselective protonation reactions is described. Structurally simple, easily accessible sulfinamides were found to induce moderate-to-high eeʼs in the formation of 2-aryl-substituted cycloalkanones from the corresponding trimethylsilyl enol ethers.Other Sources
https://www.ncbi.nlm.nih.gov/pubmed/21786775Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:8737993
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