dc.contributor.author | Alexeeff, Stacey E. | |
dc.contributor.author | Coull, Brent Andrew | |
dc.contributor.author | Gryparis, Alexandros | |
dc.contributor.author | Suh, Helen | |
dc.contributor.author | Sparrow, David | |
dc.contributor.author | Vokonas, Pantel S. | |
dc.contributor.author | Schwartz, Joel David | |
dc.date.accessioned | 2012-06-05T00:26:17Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Alexeeff, Stacey E., Brent Andrew Coull, Alexandros Gryparis, Helen Suh, David Sparrow, Pantel S. Vokonas, and Joel David Schwartz. 2011. Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function. Environmental Health Perspectives 119(4): 481-486. | en_US |
dc.identifier.issn | 0091-6765 | en_US |
dc.identifier.issn | 1552-9924 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8830769 | |
dc.description.abstract | Background: Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. Objectives: We examined the association between medium-term concentrations of black carbon (BC) estimated by land-use regression and levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), both markers of inflammatory and endothelial response. Methods: We studied 642 elderly men participating in the Veterans Administration (VA) Normative Aging Study with repeated measurements of sICAM-1 and sVCAM-1 during 1999–2008. Daily estimates of BC exposure at each geocoded participant address were derived using a validated spatiotemporal model and averaged to form 4-, 8-, and 12-week exposures. We used linear mixed models to estimate associations, controlling for confounders. We examined effect modification by statin use, obesity, and diabetes. Results: We found statistically significant positive associations between BC and sICAM-1 for averages of 4, 8, and 12 weeks. An interquartile-range increase in 8-week BC exposure \((0.30 μg/m^3)\) was associated with a 1.58% increase in sICAM-1 (95% confidence interval, 0.18–3.00%). Overall associations between sVCAM-1 and BC exposures were suggestive but not statistically significant. We found a significant interaction with diabetes—where diabetics were more susceptible to the effect of BC—for both sICAM-1 and sVCAM-1. We also observed an interaction with statin use, which was statistically significant for sVCAM-1 and suggestive for sICAM-1. We found no evidence of an interaction with obesity. Conclusion: Our results suggest that medium-term exposure to TRAP may induce an increased inflammatory/endothelial response, especially among diabetics and those not using statins. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.isversionof | doi:10.1289/ehp.1002560 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080929 | en_US |
dash.license | LAA | |
dc.subject | adhesion molecules | en_US |
dc.subject | air | en_US |
dc.subject | cardiovascular | en_US |
dc.subject | environmental | en_US |
dc.subject | outdoor air | en_US |
dc.subject | roadway proximity | en_US |
dc.title | Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Environmental Health Perspectives | en_US |
dash.depositing.author | Coull, Brent Andrew | |
dc.date.available | 2012-06-05T00:26:17Z | |
dash.affiliation.other | SPH^Biostatistics | en_US |
dc.identifier.doi | 10.1289/ehp.1002560 | * |
dash.contributor.affiliated | Vokonas, Pantel | |
dash.contributor.affiliated | Coull, Brent | |
dash.contributor.affiliated | Sparrow, David | |
dash.contributor.affiliated | Schwartz, Joel | |
dc.identifier.orcid | 0000-0002-2557-150X | |