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dc.contributor.authorYim, Hyungshin
dc.contributor.authorErikson, Raymond Leo
dc.date.accessioned2012-07-06T20:38:02Z
dc.date.issued2011
dc.identifier.citationYim, Hyungshin, and Raymond Leo Erikson. 2011. Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase. Cell Cycle 10(9): 1374-1377.en_US
dc.identifier.issn1538-4101en_US
dc.identifier.issn1551-4005en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:8965559
dc.description.abstractThe accurate division of duplicated DNA is essential for maintenance of genomic stability in proliferating eukaryotic cells. Errors in DNA replication and chromosomal segregation may lead to cell death or genomic mutations that lead to oncogenic properties. Thus, tight regulation of DNA replication and mitosis is essential for maintaining genomic integrity. Cell division cycle 6 (Cdc6) is an essential factor for initiating DNA replication. Recent work shows that phosphorylation of Cdc6 by polo-like kinase 1 (Plk1), one of the essential mitotic kinases, regulates mitotic exit mediated by Cdk1 and separase. Here we discuss how pre-replicative complex factors are connected with Plk1 and affect mitotic exit.en_US
dc.description.sponsorshipMolecular and Cellular Biologyen_US
dc.language.isoen_USen_US
dc.publisherLandes Bioscienceen_US
dc.relation.isversionofdoi:10.4161/cc.10.9.15489en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/21519187en_US
dash.licenseOAP
dc.subjectpolo-like kinase 1en_US
dc.subjectcell division cycle 6en_US
dc.subjectDNA replicationen_US
dc.subjectmitotic exiten_US
dc.subjectchromosomal segregationen_US
dc.titleRegulation of the Final Stage of Mitosis by Components of the Pre-Replicative Complex and a Polo Kinaseen_US
dc.typeJournal Articleen_US
dc.description.versionAuthor's Originalen_US
dc.relation.journalCell Cycleen_US
dash.depositing.authorErikson, Raymond Leo
dc.date.available2012-07-06T20:38:02Z
dc.identifier.doi10.4161/cc.10.9.15489*
dash.contributor.affiliatedYim, Hyungshin
dash.contributor.affiliatedErikson, Raymond


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