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dc.contributor.authorMothe, Beatriz
dc.contributor.authorLlano, Anuska
dc.contributor.authorIbarrondo, Javier
dc.contributor.authorZamarreño, Jennifer
dc.contributor.authorSchiaulini, Mattia
dc.contributor.authorMiranda, Cristina
dc.contributor.authorRuiz-Riol, Marta
dc.contributor.authorBerger, Christoph T.
dc.contributor.authorHerrero, M. José
dc.contributor.authorPalou, Eduard
dc.contributor.authorPlana, Montse
dc.contributor.authorRolland, Morgane
dc.contributor.authorHeckerman, David
dc.contributor.authorWeiner, David
dc.contributor.authorParedes, Roger
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorFelber, Barbara K.
dc.contributor.authorPavlakis, George N.
dc.contributor.authorMullins, James I.
dc.contributor.authorBrander, Christian
dc.contributor.authorKhatri, Ashok
dc.contributor.authorPereyra, Florencia M.
dc.contributor.authorWalker, Bruce David
dc.date.accessioned2012-08-08T14:31:05Z
dc.date.issued2012
dc.identifier.citationMothe, Beatriz, Anuska Llano, Javier Ibarrondo, Jennifer Zamarreño, Mattia Schiaulini, Cristina Miranda, Marta Ruiz-Riol, et al. 2012. CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control. PLoS ONE 7(1): e29717.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9369656
dc.description.abstractCytotoxic T lymphocyte (CTL) responses targeting specific HIV proteins, in particular Gag, have been associated with relative control of viral replication \(in\) \(vivo\). However, Gag-specific CTL can also be detected in individuals who do not control the virus and it remains thus unclear how Gag-specific CTL may mediate the beneficial effects in some individuals but not in others. Here, we used a 10mer peptide set spanning HIV Gag-p24 to determine immunogen-specific T-cell responses and to assess functional properties including functional avidity and cross-reactivity in 25 HIV-1 controllers and 25 non-controllers without protective HLA class I alleles. Our data challenge the common belief that Gag-specific T cell responses dominate the virus-specific immunity exclusively in HIV-1 controllers as both groups mounted responses of comparable breadths and magnitudes against the p24 sequence. However, responses in controllers reacted to lower antigen concentrations and recognized more epitope variants than responses in non-controllers. These cross-sectional data, largely independent of particular HLA genetics and generated using direct \(ex-vivo\) samples thus identify T cell responses of high functional avidity and with broad variant reactivity as potential functional immune correlates of relative HIV control.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0029717en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251596/pdf/en_US
dash.licenseLAA
dc.subjectHIVen_US
dc.subjectbiologyen_US
dc.subjectimmunologyen_US
dc.subjectimmune cellsen_US
dc.subjectimmunityen_US
dc.subjectmicrobiologyen_US
dc.subjectvirologyen_US
dc.subjectviral classificationen_US
dc.subjectclinical immunologyen_US
dc.subjectclinical research designen_US
dc.subjectviral diseasesen_US
dc.titleCTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Controlen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorPereyra, Florencia M.
dc.date.available2012-08-08T14:31:05Z
dc.identifier.doi10.1371/journal.pone.0029717*
dash.authorsorderedfalse
dash.contributor.affiliatedKhatri, Ashok
dash.contributor.affiliatedPereyra, F
dash.contributor.affiliatedWalker, Bruce


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