# Diffusion MRI Tractography of the Human Heart $$In$$ $$Vivo$$ at End-Diastole and End-Systole

 Title: Diffusion MRI Tractography of the Human Heart $$In$$ $$Vivo$$ at End-Diastole and End-Systole Author: Nielles-Vallespin, Sonia; Gatehouse, Peter D; Jackowski, Marcel P; Firmin, David N; Mekkaoui, Choukri; Sosnovik, David E. Note: Order does not necessarily reflect citation order of authors. Citation: Mekkaoui, Choukri, Sonia Nielles-Vallespin, Peter D Gatehouse, Marcel P Jackowski, David N Firmin, and David E Sosnovik. 2012. Diffusion MRI tractography of the human heart $$in$$ $$vivo$$ at end-diastole and end-systole. Journal of Cardiovascular Magnetic Resonance 14(Suppl 1): O49. Full Text & Related Files: 3305175.pdf (2.217Mb; PDF) Abstract: Diffusion Tensor MRI (DTI) of the human heart $$in$$ $$vivo$$ has to date been performed in 2D and at a single phase of the cardiac cycle. Here we perform 3D tractography of the human heart $$in$$ $$vivo$$ at both end diastole and end systole. We show that fiber orientation in the subepicardium becomes more oblique during systole, and that scalar indices of diffusion (mean diffusivity and fractional anisotropy) decrease during systole. Our data suggest that myocardial fiber architecture is dynamic and is a function of both chamber geometry and myocardial contraction. Published Version: doi:10.1186/1532-429X-14-S1-O49 Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305175/pdf/ Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9393005 Downloads of this work: