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dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorPatterson, Nick
dc.contributor.authorElizabeth, Selvin
dc.contributor.authorAkylbekova, Ermeg L.
dc.contributor.authorBrancati, Frederick L.
dc.contributor.authorCoresh, Josef
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorTaylor, Herman A.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorWilson, James G.
dc.contributor.authorReich, David Emil
dc.contributor.authorTandon, Arti
dc.contributor.authorAltshuler, David Matthew
dc.contributor.authorKao, W. H. Linda
dc.date.accessioned2012-08-10T18:17:01Z
dc.date.issued2012
dc.identifier.citationCheng, Ching-Yu, David Reich, Christopher A. Haiman, Arti Tandon, Nick Patterson, Selvin Elizabeth, Ermeg L. Akylbekova, et al. 2012. African ancestry and its correlation to type 2 diabetes in African Americans: A genetic admixture analysis in three U.S. population cohorts. PLoS ONE 7(3): e32840.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9393258
dc.description.abstractThe risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that genetic factors may explain some of this population difference in disease risk. However, relatively few genetic studies have examined this hypothesis in a large sample of African Americans with and without diabetes. Therefore, we performed an admixture analysis using 2,189 ancestry-informative markers in 7,021 African Americans (2,373 with type 2 diabetes and 4,648 without) from the Atherosclerosis Risk in Communities Study, the Jackson Heart Study, and the Multiethnic Cohort to 1) determine the association of type 2 diabetes and its related quantitative traits with African ancestry controlling for measures of SES and 2) identify genetic loci for type 2 diabetes through a genome-wide admixture mapping scan. The median percentage of African ancestry of diabetic participants was slightly greater than that of non-diabetic participants (study-adjusted difference = 1.6%, \(P\)<0.001). The odds ratio for diabetes comparing participants in the highest vs. lowest tertile of African ancestry was 1.33 (95% confidence interval 1.13–1.55), after adjustment for age, sex, study, body mass index (BMI), and SES. Admixture scans identified two potential loci for diabetes at 12p13.31 (LOD = 4.0) and 13q14.3 (Z score = 4.5, \(P\) = 6.6×10\(^{−6}\)). In conclusion, genetic ancestry has a significant association with type 2 diabetes above and beyond its association with non-genetic risk factors for type 2 diabetes in African Americans, but no single gene with a major effect is sufficient to explain a large portion of the observed population difference in risk of diabetes. There undoubtedly is a complex interplay among specific genetic loci and non-genetic factors, which may both be associated with overall admixture, leading to the observed ethnic differences in diabetes risk.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0032840en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306373/pdf/en_US
dash.licenseLAA
dc.subjectbiologyen_US
dc.subjectgeneticsen_US
dc.subjectheredityen_US
dc.subjecthuman geneticsen_US
dc.subjectpopulation geneticsen_US
dc.subjectmedicineen_US
dc.subjectendocrinologyen_US
dc.subjectdiabetic endocrinologyen_US
dc.subjectepidemiologyen_US
dc.subjectnutritionen_US
dc.subjectpublic healthen_US
dc.titleAfrican Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohortsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorReich, David Emil
dc.date.available2012-08-10T18:17:01Z
dc.identifier.doi10.1371/journal.pone.0032840*
dash.authorsorderedfalse
dash.contributor.affiliatedAltshuler, David
dash.contributor.affiliatedTandon, Arti
dash.contributor.affiliatedReich, David


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